Publications by Sz-Hao Chu

Publications by authors named "Sz-Hao Chu"

Page 1 of 1

Chidamide plus Tyrosine Kinase Inhibitor Remodel the Tumor Immune Microenvironment and Reduce Tumor Progression When Combined with Immune Checkpoint Inhibitor in Naïve and Anti-PD-1 Resistant CT26-Bearing Mice.

Jia-Shiong Chen Yi-Chien Hsieh Cheng-Han Chou Yi-Hong Wu Mu-Hsuan Yang Sz-Hao Chu

Int J Mol Sci

September 2022

Article Synopsis

The combination of chidamide, a histone deacetylase inhibitor, with VEGF TKIs and immune checkpoint inhibitors shows enhanced efficacy in treating murine colon carcinoma compared to using these therapies alone.
The research indicates that this combination therapy improves tumor response and overall survival in cancer models, even in those resistant to PD-1 treatment.
Analysis of the tumor microenvironment revealed that this optimal combination reduces immunosuppressive cells and boosts T-cell activation, leading to better therapeutic outcomes.

View Article and Find Full Text PDF

CC-01 (chidamide plus celecoxib) modifies the tumor immune microenvironment and reduces tumor progression combined with immune checkpoint inhibitor.

Jia-Shiong Chen Cheng-Han Chou Yi-Hong Wu Mu-Hsuan Yang Sz-Hao Chu

Sci Rep

January 2022

Immune checkpoint inhibitors (ICIs) have shown clinical benefit in solid tumors, with modest rates of clinical response. Hence, improved therapeutic approaches need to be investigated. Herein, we assessed a combination of chidamide plus celecoxib (called CC-01) combined with programmed cell death protein 1 (PD-1) blockade in a CT26 model as potent tumor microenvironment (TME) regulator.

View Article and Find Full Text PDF