Water-generated negative air ions activate NK cell and inhibit carcinogenesis in mice.

Negative ions are considered to have potential health benefits, but few studies have examined their effects in vivo. We studied water-generated negative ions (WNI) with respect to physical properties as well as immunologic activation and anti-tumor activity (inhibition of carcinogenesis and tumor growth) in mice. Electrically, generated negative ions (ENI) served as control.

Expression of Epstein-Barr virus in thyroid carcinoma correlates with tumor progression.

There have been few studies regarding cancer progression from differentiated thyroid carcinoma to the undifferentiated one. To examine the possible involvement of Epstein-Barr virus (EBV) in this progression, 10 papillary carcinomas and 11 undifferentiated carcinomas were subjected to mRNA in situ hybridization, indirect immunofluorescence staining, polymerase chain reaction (PCR), and reverse-transcriptase PCR. mRNA in situ hybridization using a BamHIW probe revealed signals in all of the examined samples, although the signal strength was weaker in the papillary carcinomas than in the undifferentiated carcinomas.

Inhibition of peritoneal metastasis in an animal gastric cancer model by interferon-gamma and interleukin-2.

Background: The anti-tumor activity of interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) have been shown in human gastric cancer cell lines, however, their therapeutic effects on peritoneal metastasis have not been investigated.

Materials And Methods: The anti-tumor activity of IFN-gamma and IL-2 against the gastric cancer cell line, MKN45, was evaluated by in vitro antiproliferation assays and in animal-tumor models of intraperitoneal (i.p.