[Influence repeated stress on immune responciveness and monooxigenase activity of normotensive and hypertensive rats].

Repeated stress led to antipodal directions in immune system and cytochrome P450 activities of normotensive and hypertensive rats. Enhancement of the Reaction of Delayed Hypersensitivity, suppression of cytochrome P450-mediated monooxigenase activities were observed in Wistar rats. On the contrary, in the NISAG decrease of the Reaction Delayed Hypersensitivity, elevation of cytochrome P450-mediated monooxigenase activities were observed, as comparison with Wistar rats.

Activation of apoptosis as a mechanism of thymus involution during repeated immobilization.

Lymphopenia preceded involution of the thymus during daily immobilization for 1 h. Hypoplasia of the thymus was associated with induction of apoptosis.