Increasing the security and traceability of biological samples in biobanks by blockchain technology.

Background And Objective: One of the main tasks in a biobank consists in storing biological samples in a high-quality condition in order to future research. At moment, there exist many applications to manage a biobank. However, in general, these are web-based applications.

Multilocular cystic nephroma: A clinical case.

Objective: To describe the clinical presentation, preoperative diagnostic possibilities, and treatment of cystic nephroma.

Methods: We describe a case of cystic nephroma in an adult male and show that, both in our patient and in the literature, a definitive diagnosis can only be obtained postoperatively, even when there is a reasonable clinical suspicion.

Conclusions: Cystic nephroma is rare, and some authors consider it a questionable entity.

ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma.

Extracellular signal-regulated kinase 5 (ERK5), also known as big mitogen-activated protein kinase (MAPK) 1, is implicated in a wide range of biologic processes, which include proliferation or vascularization. Here, we show that ERK5 is degraded through the ubiquitin-proteasome system, in a process mediated by the tumor suppressor von Hippel-Lindau (VHL) gene, through a prolyl hydroxylation-dependent mechanism. Our conclusions derive from transient transfection assays in Cos7 cells, as well as the study of endogenous ERK5 in different experimental systems such as MCF7, HMEC, or Caki-2 cell lines.

Median raphe cyst. Report of two cases and literature review.

Objectives: To report 2 cases of median raphe cysts, 1 in the penis and the other in the perineum.

Method: Two cases of median raphe cyst are described; the first was treated by surgery and the second required no treatment.

Results: The surgical patient experienced no complications and was asymptomatic with no recurrence at 2 years.

Alopecia syphilitica with detection of Treponema pallidum in the hair follicle.

Alopecia is one of the clinical manifestations of secondary syphilis. It is uncommon for hair loss to be the sole or predominant manifestation, as hair loss is the chief clinical and histologic differential diagnosis of alopecia areata. The main difference between these two entities is the detection of Treponema pallidum in syphilis.

Polymorphous low-grade adenocarcinoma of the palate: report of cases.

Objective: Polymorphous low-grade adenocarcinoma (PLGA) is a rare tumor that mostly affects minor salivary glands. The purpose of this study is to report six new cases followed-up during a long period. We also review the literature concerning clinical, histological and immunohistochemical features, as well as the proper management.

Melanoma of the oral mucosa. Clinical cases and review of the literature.

The appearance of primary melanomas of the oral mucosa is uncommon. The aggressiveness of this entity and the absence of any standardized treatment protocol make the prognostic unfortunate. The difficulty to obtain free surgical margins, the elevated tendency to invade in depth and the early haematogenous metastasis have been referred as features which may explain its bad prognosis, even in comparison with cutaneous melanoma.