Intragastric infusion of glucose enhances the rewarding effect of sorbitol fatty acid ester ingestion as measured by conditioned place preference in mice.

We investigated substances that induce a rewarding effect during the postingestive process using the conditioned place preference (CPP) test. Although mice showed high affinity for a low-energy fat substitute--sorbitol fatty acid esters and low-concentration linoleic acid solution--they did not exhibit a place preference toward a voluntary intake of fat substitute in the CPP test. However, during a conditioning session of CPP that involved intragastric administration of corn oil immediately before the intake of the fat substitute, the test mice displayed a place preference.