Publications by authors named "Synthia F Bethea"
Article Synopsis
- Cortistatin (CST) is a newly identified neuropeptide with anti-inflammatory properties that may play a role in intervertebral disc degeneration.
- * The study aimed to explore CST's presence in human disc tissue, its expression influenced by TNF-α, and its effect on cell proliferation through methods like immunohistochemistry and in vitro cultures.
- * Results showed CST in various parts of the disc and that higher TNF-α levels reduced CST expression while CST exposure increased cell proliferation, suggesting that inflammation may diminish CST's beneficial effects in degenerating discs.
Background Context: Mitochondrial dysfunction is recognized during cell senescence and apoptosis, two important components of human disc aging/degeneration. We hypothesize that mitochondrial dysfunction is present in the degenerating and senescent annulus cells. The objective of the present study was to analyze gene expression profiles related to mitochondrial function in vivo.
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