Publications by authors named "Symone V Jordan"
The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the United States, using CLIA-certified mass spectrometry-based assays. We investigate their associations with population groups (Ghanaian, African American, European American men), lifestyle factors, the fatty acid desaturase (FADS) genetic locus, and prostate cancer.
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- * A study of nearly 3000 men reveals that those of West African ancestry have higher levels of proteins that suppress tumor immunity and influence chemotaxis, which are linked to worse outcomes in prostate cancer.
- * Specific markers, such as pleiotrophin and TNFRSF9, predict poorer survival rates in African American men, highlighting the need for tailored cancer therapies to address these disparities.
Sexually transmitted infections can reach the prostate gland where their harmful effects are mediated by innate immunity, including interferons. Humans are polymorphic for the germline dinucleotide variant, rs368234815-TT/ΔG, in the gene encoding interferon λ4. Since the ΔG allele has been linked to impaired viral clearance, we hypothesized that potential exposure to sexually transmitted pathogens, as assessed by the number of lifetime sexual partners, may increase prostate cancer risk in an ΔG-dependent manner.
View Article and Find Full Text PDFMen of African ancestry experience an excessive prostate cancer mortality that could be related to an aggressive tumor biology. We previously described an immune-inflammation signature in prostate tumors of African-American (AA) patients. Here, we further deconstructed this signature and investigated its relationships with tumor biology, survival, and a common germline variant in the IFNλ4 () gene.
View Article and Find Full Text PDFAspirin Use Reduces the Risk of Aggressive Prostate Cancer and Disease Recurrence in African-American Men.
Cancer Epidemiol Biomarkers Prev
June 2017
Men of African descent experience a disproportionately high prostate cancer mortality. Intratumoral inflammation was found to be associated with aggressive prostate cancer. We and others have shown that prostate tumors in African-American (AA) patients harbor a distinct immune and inflammation signature when compared with European-American (EA) patients.
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- Smokers have a higher rate of metastatic prostate cancer compared to nonsmokers, indicating that substances from tobacco may promote cancer progression.
- Researchers found that tumors from current smokers displayed unique gene and protein changes related to immune response and inflammation, which were less pronounced or absent in tumors from past or never smokers.
- Additionally, studies on nicotine effects showed that it heightened cancer cell invasiveness and sped up metastatic growth in mice, highlighting nicotine as a possible key factor in the development of aggressive prostate cancer in smokers.