Publications by authors named "Sylwia Szwiega"
Article Synopsis
- - Previous research suggested leucine needs for adults might range from 25 to 40 mg⋅kg⋅d, with new data indicating a potential requirement of up to 55 mg⋅kg⋅d, but this study specifically focused on young adult males using a method called indicator amino acid oxidation (IAAO).
- - The study involved ten healthy young males who were given varying amounts of leucine (from 10 to 75 mg⋅kg⋅d) over a three-day period to assess their leucine requirements while monitoring biochemical responses.
- - Results indicated that the average leucine requirement for these males was approximately 33.6 mg⋅kg⋅d, which supports prior findings and
Background: Current recommendation for lysine in older adults, 30 mg/kg/d, is based on young adult data. Evidence suggests that amino acid requirements may differ between young and old adults with both sex and age having an effect in the elderly.
Objectives: This study aimed to define the lysine requirements in healthy older adults using the indicator amino acid oxidation (IAAO) method with L-[1-C] phenylalanine as the indicator and to compare the derived estimates based on age: 60-69 y and >70 y.
Article Synopsis
- In 2005, the Institute of Medicine recommended using methods other than nitrogen balance to determine protein requirements, leading to new calculations using indicator amino acid oxidation, which suggested higher protein needs.
- This study aimed to analyze the impact of various protein intakes (0.6 to 1.5 g/kg/d) on erythrocyte glutathione (GSH) kinetics in healthy adults, focusing specifically on the synthesis rates of GSH.
- Results indicated that a protein intake of 1.0 g/kg/d maximized GSH fractional synthesis rate, while higher protein intakes increased urinary sulfate without affecting other plasma oxidative stress markers or GSH levels.
Background: The indicator amino acid oxidation (IAAO) method is minimally invasive; therefore, it is applicable to study the amino acid (AA) requirements of individuals in various age groups. However, the accuracy of this method has been criticized because of the 8 h (1 d) protocol, which has been suggested to be too short an adaptation time for estimating AA requirements.
Objectives: The IAAO method was used to determine whether 3 or 7 d of adaptation to each threonine intake alters the threonine requirement in adult men compared to 1 d of adaptation.
Determination of indispensable amino acid (IAA) requirements necessitates a range of intakes of the test IAA and monitoring of the physiological response. Short-term methods are the most feasible for studying multiple intake levels in the same individual. Carbon oxidation methods measure the excretion of CO in breath from a labelled amino acid (AA) in response to varying intakes of the test AA following a period of adaptation.
View Article and Find Full Text PDFBackground: Current national (34 mg . kg-1 . d-1) and international (39 mg kg-1 .
View Article and Find Full Text PDFBackground: The phenylalanine requirement of the elderly is not known. Current recommendations are based on studies in young adults and are derived from a combined estimate of the total aromatic amino acids, phenylalanine, and tyrosine.
Objectives: The purpose of this study was to determine the dietary phenylalanine requirement of adults aged >65 y, using the direct amino acid oxidation method, by measuring the oxidation of l-[1-13C]phenylalanine to 13CO2 in response to graded phenylalanine intakes in the presence of excess tyrosine.
Background: The conduct of high-quality pilot studies can help inform the success of larger clinical trials. Guidelines have been recently developed for the reporting of pilot trials.
Objective: This methodological survey evaluates the completeness of reporting in pilot randomized controlled trials in chronic kidney disease patients on hemodialysis (HD patients) and explores factors associated with better completion of reporting.