Pluronics-Based Drug Delivery Systems for Flavonoids Anticancer Treatment.

This research concerns the investigation of the preparation of polymeric nanocarriers containing a flavonoid-naringenin, xanthohumol or isoxanthohumol-based on Pluronics by the thin-film formation method. The size of the formed micelles and their stability upon dilution were evaluated using Dynamic light scattering (DLS) analysis; the high values of the drug loading and the encapsulation efficiency confirmed that the proposed systems of flavonoids delivery consisting of Pluronic P123 and F127 nanomicelles could effectively distribute the drug into tumour tissues, which makes these nanocarriers ideal candidates for passive targeting of cancer cells by the enhanced permeation and retention (EPR) effect. The in vitro cytotoxicity of proposed flavonoids in the Pluronic formulations was investigated by the SRB assay with human colon cancer cells.

Kinetics, Thermodynamics and Equilibrium Studies for Gold Recovery from Diluted Waste Solution.

2,2'-thiobisethanol dimethacrylate/ethylene glycol dimethacrylate copolymer (coP-TEDMA/EGDMA) was used as a sorbent for gold recovery from residual solutions resulting from the electroplating industry. Firstly, synthesized material was characterized by X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, and confocal laser scanning microscopy. The sorption process mechanism was evidenced on the basis of kinetic, thermodynamic and equilibrium studies.

Sorption Properties of Specific Polymeric Microspheres towards Desethyl-Terbuthylazine and 2-Hydroxy-Terbuthylazine: Batch and Column Studies.

This work investigates the sorption properties of poly(divinylbenzene) modified in the Diels-Alder reaction towards persistent and mobile metabolites of terbuthylazine. The batch experiments were carried out to examine the efficiency of desethyl-terbuthylazine and 2-hydroxy-terbuthylazine adsorption on the specific adsorbent and the impact of different factors on the adsorption process. Results fit well to a pseudo-second order kinetic model.

Hydrophobically Functionalized Poly(Acrylic Acid) Comprising the Ester-Type Labile Spacer: Synthesis and Self-Organization in Water.

One of the most important properties of hydrophobically functionalized polyelectrolytes (HF-PEs) and their assemblies is their ability to encapsulate hydrophobic/amphiphilic agents and provide release on demand of the entrapped payload. The aim of the present work was to synthesize and study self-organization behavior in aqueous solution of hydrophobically functionalized poly(acrylic acid) (PAA) comprising the ester-type pH labile moiety with various degrees of hydrophobization and side-chain lengths in the absence and presence of appropriate mono- and polyvalent electrolytes (i.e.

Nanostructured synthetic carbons obtained by pyrolysis of spherical acrylonitrile/divinylbenzene copolymers.

Novel carbon materials have been prepared by the carbonization of acrylonitrile (AN)/divinylbenzene (DVB) suspension porous copolymers having nominal crosslinking degrees in the range of 30-70% and obtained in the presence of various amounts of porogens. The carbons were obtained by pre-oxidation of AN/DVB copolymers at 250-350°C in air followed by pyrolysis at 850°C in an N(2) atmosphere. Both processes were carried out in one furnace and the resulting material needed no further activation.

Comparison of different imidazolium supported ionic liquid polymeric phases with strong anion-exchange character for the extraction of acidic pharmaceuticals from complex environmental samples.

Two imidazolium supported ionic liquid phases (SILPs) containing different anions, trifluoromethanesulphonate [CF(3)SO(3)(-)], and tetrafluoroborate [BF(4)(-)], were synthesized and evaluated as solid-phase extraction sorbents for extracting acidic pharmaceuticals from aqueous samples under strong anion-exchange conditions, which include an effective cleanup of the sample. The best SILP material [MI(+)][CF(3)SO(3)(-) ] was selected and successfully applied to the determination of acidic pharmaceuticals in different types of water samples (river water and effluent wastewater). The results were then compared to the previously synthesized SILP material based on [MI(+)][CF(3)COO(-)] and the commercially available Oasis MAX sorbent.

Supported imidazolium ionic liquid phases: a new material for solid-phase extraction.

This study reports a material that is based on the concept of ionic liquid analogue: a slightly crosslinked polymer-supported imidazolium trifluoroacetate salt (IL-CF(3)COO(-)) that favorably combines the properties of ionic liquids (ILs) and the advantages of a solid support. The ionic liquid-supported material was evaluated for the first time as a solid-phase extraction (SPE) sorbent for selectively and quantitatively extracting pharmaceuticals from aqueous samples. The novel IL-CF(3)COO(-) was evaluated under reversed-phase (RP), weak anion exchange (WAX), strong anion exchange (SAX) and strong cation exchange (SCX) SPE procedures, and we found that SAX conditions are the most suitable for investigating the behaviour of the IL-CF(3)COO(-) material.