Publications by authors named "Sylviya Ganeshamoorthy"
Introduction: Funders must make difficult decisions about which squared treatments to prioritize for randomized trials. Earlier research suggests that experts have no ability to predict which treatments will vindicate their promise. We tested whether a brief training module could improve experts' trial predictions.
View Article and Find Full Text PDFBackground: Pharmaceutical industry exposure is widespread during medical training and may affect education and clinical decision-making. Medical faculties' conflict of interest (COI) policies help to limit this exposure and protect students against commercial influence.
Aims: Our aim was to investigate the prevalence, content and strength of COI policies at Australian medical schools and changes since a previous assessment conducted in 2009.
Major ethics policies require that human studies be preceded by animal experiments. We probed the extent to which trials testing efficacy of cancer drugs cited preclinical efficacy studies testing the same drug and disease indication. Using a sample of Phase 2 trial publications for novel cancer monotherapies approved by Food and Drug Administration 2005-2007, we conducted a systematic analysis of citations to preclinical efficacy evidence within trial publications.
View Article and Find Full Text PDFArticle Synopsis
- This systematic review aims to identify and quantify brain structural abnormalities in adolescents and young adults with complex congenital heart defects (CHD) and explore their impact on functional outcomes.
- The research involved a comprehensive search and meta-analysis of studies using MRI to assess brain structure, revealing that individuals with CHD have 7.9 times higher odds of brain abnormalities compared to their typically developing peers.
- The findings indicate a high prevalence of brain abnormalities, including specific lesions, and suggest a link between these abnormalities and poorer neurocognitive performance, emphasizing the need for further research to understand the functional implications.