Publications by authors named "Sylvie Vande Velde"
Adipose tissue homeostasis relies on the interplay between several regulatory lineages, such as type 2 innate lymphoid cells (ILC2s), T helper 2 (Th2) cells, regulatory T cells, eosinophils, and type 2 macrophages. Among them, ILC2s are numerically the dominant source of type 2 cytokines and are considered as major regulators of adiposity. Despite the overlap in immune effector molecules and sensitivity to alarmins (thymic stromal lymphopoietin and interleukin-33) between ILC2s and resident memory Th2 lymphocytes, the role of the adaptive axis of type 2 immunity remains unclear.
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- Oesophageal cancer (OEC) has a low survival rate, highlighting the need for effective prognostic markers, particularly the histopathological growth pattern (HGP) as a potential indicator.
- A study analyzed HGP in two cohorts: one from The Cancer Genome Atlas with 89 untreated patients and another with 99 treated patients from Belgium, by evaluating H&E stained images and gene expression data.
- Results showed that patients with infiltrative growth patterns (IGP) had worse outcomes and were linked to more aggressive tumor features, while pathways like angiogenesis, epithelial-to-mesenchymal transition, and inflammation were significantly activated in IGP samples compared to expansive growth patterns (EGP).