Publications by authors named "Sylvie LeGall"
Article Synopsis
- Increased PD-L1 expression is seen in individuals infected with HIV-1, but the exact reasons for this rise are not fully understood.
- Researchers found that Toll-like receptor (TLR) 7/8 ligands derived from HIV-1 trigger a MyD88-dependent increase of PD-L1 on various immune cells, such as plasmacytoid and myeloid dendritic cells as well as monocytes.
- This mechanism may explain how HIV-1 influences the impairment of virus-specific T cells that express PD-1 by promoting higher levels of PD-L1 on antigen-presenting cells.
