Publications by authors named "Sylvie Giard"
Background: Sentinel lymph node biopsy (SLNB) remains under discussion for large size tumors. The aim of this work has been to study the false negative rate (FNR) of SLNB for large tumors and predictive factors of false negative (FN).
Materials And Methods: A study of a multicentric cohort, involved patients presenting N0 breast cancer with a SLNB eventually completed by complementary axillary lymph node dissection (cALND).
Background: To estimate the proportion of elderly patients (>70 years) with breast cancer eligible for an Exclusive IntraOperative RadioTherapy (E-IORT) and to evaluate their local recurrence-free survival rate.
Methods: This retrospective study examining two cohorts focuses on patients over 70 years old: a multi-centric cohort of 1411 elderly patients and a mono-centric cohort of 592 elderly patients. All patients underwent conservative surgery followed by external radiotherapy for T0-T3 N0-N1 invasive breast cancer, between 1980 and 2008.
Article Synopsis
- - The study analyzed 14,095 breast cancer patients to determine the rate and factors affecting axillary recurrence (AR) after sentinel lymph node biopsy, finding an overall AR rate of just 0.51% during a median follow-up of 55.2 months.
- - Key predictors for AR included higher tumor grades, lack of radiotherapy, and specific tumor subtypes, particularly noting higher AR rates in triple-negative and HER2-positive tumors.
- - AR was significantly associated with lower overall survival rates, particularly in patients with early-onset AR, highlighting the need for systemic treatment in cases of isolated AR, though the actual benefits of such treatments are still unclear.
Purpose: To determine the rate of nonsentinel lymph node (NSN) involvement at axillary lymph node dissection (ALND) and predictive factors of this involvement following detection of micrometastasis in sentinel nodes (SN).
Methods: We analyzed 700 observations of SN micrometastases with additional ALND with the characteristics of the patients, tumors, and SN.
Results: Involvement of SN was diagnosed 388 times by serial sections (55.
Objective: To perform sentinel node with local anaesthesia in the breast carcinoma without frozen section. So we used definitive histological and immunohistochemical results of sentinel node the day of conserving surgery with complete axillary lymph node dissection under general anaesthesia in case of involved nodes.
Methods: Patients with a stage TNM > T1 or N1, a multicentric breast cancer, a neoadjuvant chemotherapy, an allergy, an obesity or no detection of hot sentinel node were excluded.