International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium.

We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries (www.covidclinical.

Preservation of information in terminology transcoding.

Linking interface terminologies (IT) to reference terminologies (RT) in flow of terminologies may allow health information system to be both usable and interoperable. Two French university hospitals worked independently on such a flow from the prescription of lab-test to the display of the corresponding results. The aim of this study was to evaluate the transmission of information in these two hospitals communication.

Implementation and management of a biomedical observation dictionary in a large healthcare information system.

Objective: This study shows the evolution of a biomedical observation dictionary within the Assistance Publique Hôpitaux Paris (AP-HP), the largest European university hospital group. The different steps are detailed as follows: the dictionary creation, the mapping to logical observation identifier names and codes (LOINC), the integration into a multiterminological management platform and, finally, the implementation in the health information system.

Methods: AP-HP decided to create a biomedical observation dictionary named AnaBio, to map it to LOINC and to maintain the mapping.

Implementation of a platform dedicated to the biomedical analysis terminologies management.

Background And Objectives: Assistance Publique - Hôpitaux de Paris (AP-HP) is implementing a new laboratory management system (LMS) common to the 12 hospital groups. First step to this process was to acquire a biological analysis dictionary. This dictionary is interfaced with the international nomenclature LOINC, and has been developed in collaboration with experts from all biological disciplines.

Construction of a dictionary of laboratory tests mapped to LOINC at AP-HP.

We report on the ongoing process implemented at Assistance Publique-Hôpitaux de Paris (AP-HP), the largest hospital system in Europe, to build a common reference for laboratory tests in French with LOINC mappings. At the time of writing, it contained 24,000 tests, covering all fields of biology, in use in 19 AP-HP hospitals, 30% of which had a mapping to LOINC with a peak of over 60% in biochemistry.

Features of the metabolic syndrome of "hypertriglyceridemic waist" and transplant coronary artery disease.

Background: This study evaluated the prevalence of the atherogenic metabolic triad and the hypothesis that waist circumference and fasting triglyceride concentrations could be used as screening tools for identification of the atherogenic metabolic triad in a population of heart transplant men. It also evaluated the relationship between the atherogenic metabolic triad and coronary artery disease (CAD).

Methods: In the study group of 83 consecutive male heart transplant patients having their routine annual coronarography, 23 patients (28%) were characterized by the atherogenic metabolic triad defined by the presence of elevated fasting insulin and apolipoprotein B concentrations and by small low-density lipoprotein (LDL) particles.

Tumor antigen markers for the detection of solid cancers in inflammatory myopathies.

Dermatomyositis and polymyositis patients have an increased risk of developing cancers. We have assessed the diagnostic values of serum tumor markers for the detection of solid cancer in dermatomyositis/polymyositis patients. Serum carcinoembryonic antigen, CA15-3, CA19-9, and CA125 were assayed by immunoradiometric methods in 102 dermatomyositis/polymyositis patients.

Cortisol diurnal variation in blood and saliva of patients with metastatic colorectal cancer: relevance for clinical outcome.

Background: In healthy humans, cortisol displays marked 24-hour rhythms in serum and saliva, with a strong correlation between both fluids; the circadian variation of salivary cortisol is prognostic of longer survival in patients with metastatic breast cancer. In order to confirm these results in a non-hormone-dependent cancer, cortisol concentrations in serum and saliva were compared at different circadian stages, in patients with metastatic colorectal cancer.

Patients And Methods: A first study consisted of round-the-clock sampling for two 24-hour periods, in 18 patients.