Publications by authors named "Sylvie Broussous"
Article Synopsis
- The study aimed to compare the effectiveness of an intradiscal injection of allogeneic bone marrow mesenchymal stromal cells (BM-MSCs) to a sham placebo in chronic low back pain patients.
- 114 participants were randomly assigned to receive either the BM-MSC injection or a placebo, and outcomes were measured over 12 months using pain and disability scales, along with MRI assessments.
- The results showed no significant difference in effectiveness between the BM-MSC and placebo groups after 12 months, although the procedure was deemed safe with no serious adverse events reported.
Objectives: To evaluate the outcomes of hypospadias surgery according to age and to determine if some complications are age-related.
Patients And Methods: This retrospective study was based on 722 boys with hypospadias undergoing primary repair. A total of 501 boys underwent urethroplasty and were included in the study.
Article Synopsis
- A study in southern France explored the link between exposure to endocrine-disrupting chemicals (EDCs) and isolated hypospadias in children, finding a significant association between increased fetal exposure to EDCs and the occurrence of this condition.
- The research involved 408 children with isolated hypospadias and 302 healthy boys, assessing parental occupational and environmental exposures to EDCs using questionnaires and job-exposure matrices, particularly focusing on the period during which genital differentiation occurs.
- Results indicated that fetal exposure to EDCs was much higher in hypospadias cases (40%) compared to controls (17%), with mothers in specific occupations like cleaning and hairdressing showing increased exposure levels.
The synthesis based on palladium catalytic coupling of 38 new-arylated benzo[b]thiophenes or thiophenes is described in a few steps. We also report the direct arylation of the position 3 of the benzo[b]thiophenic structure, a 'one pot' 2,5-heterodiarylation of thiophenes as well as the synthesis of precursors of amino-acids with a 2-arylated benzo[b]thiophene core. These compounds were evaluated on bacteria strains: most of them did not exhibit any antibiotic activity but were found to selectively inhibit the NorA multidrug transporter of Staphylococcus aureus.
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