Steroids in aminoglycoside-containing ear drops: do they reduce cochlear toxicity?

Objectives/hypothesis: To determine whether betamethasone (BM) reduces the cochlear toxicity of otic gentamicin (GM) if given together.

Study Design: Controlled animal study.

Methods: Thirty-four mice were assigned at random to receive intratympanic injections of either 0.

End points for cisplatin ototoxicity.

Introduction: Hearing loss owing to ototoxicity in humans is usually presumed to be irreversible and stable. Most articles in the literature study the effects of ototoxic agents such as cisplatin only over a few days or weeks. This study focused on the recovery of hearing over several months in mice.

Does sodium thiosulphate delay presbyacusis?

Introduction: This study compares the effects of sodium thiosulphate (STS) and normal saline on the prevention of hearing loss.

Setting: Animal research laboratory.

Methods: Sixteen mice were randomized to receive intraperitoneal injections of either normal saline or STS.