Publications by authors named "Sylvia von Karstedt"
Article Synopsis
- Malignant mesothelioma (MM) is a severe cancer that doesn't respond well to traditional chemotherapy and is usually fatal. A recent study screened 94 drugs on 15 MM cell lines to identify effective treatments.
- The researchers found that certain MM cases with loss-of-function mutations in the BAP1 gene showed increased sensitivity to TRAIL, a drug that induces cancer cell death. This was confirmed in multiple test models, including human tissues and mouse studies.
- Since BAP1 mutations are common in MM, they could be used as a biomarker to predict which patients might benefit from TRAIL treatment, potentially leading to better-targeted therapies for this aggressive cancer.
