Prognostic role of protease-activated receptors 1 and 4 in resected stage IB non-small-cell lung cancer.

Background: Protease-activated receptor (PAR)-1 and PAR-4 are involved in extracellular matrix invasion and angiogenesis.

Patients And Methods: A series of 60 resected stage IB non-small-cell lung cancers (NSCLCs), including 30 adenocarcinomas (ADCs) and 30 squamous cell carcinomas (SCCs), were processed by immunohistochemistry with antibodies to PAR-1, PAR-4, vascular endothelial growth factor (VEGF), and CD34.

Results: Protease-activated receptor-1 was expressed in 37 cases (62%) and PAR-4 in 39 (65%).