Publications by authors named "Sylvia Lambot"
Article Synopsis
- Graft-versus-host disease (GvHD) is a serious problem that can happen after getting a stem cell transplant.
- Researchers found that a special kind of cells called DP8α Tregs, which help control the immune system, might help prevent GvHD by linking to helpful gut bacteria.
- The study showed that patients with fewer DP8α Tregs were more likely to develop GvHD, suggesting that boosting these cells could be important for preventing this disease.
Immune checkpoint (IC) blockade and adoptive transfer of tumor-specific T-cells (ACT) are two major strategies to treat metastatic melanoma. Their combination can potentiate T-cell activation in the suppressive tumor microenvironment, but the autoimmune adverse effects associated with systemic injection of IC blockers persist with this strategy. ACT of tumor-reactive T-cells defective for IC expression would overcome this issue.
View Article and Find Full Text PDFRecent findings suggest that S100A4, a protein involved in communication between stromal cells and cancer cells, could be more involved than previously expected in cancer invasiveness. To investigate its cumulative value in the multistep process of the pathogenesis of malignant mesothelioma (MM), SWATH-MS (sequential window acquisition of all theoretical fragmentation spectra), an advanced and robust technique of quantitative proteomics, was used to analyze a collection of 26 preneoplastic and neoplastic rat mesothelial cell lines and models of MM with increasing invasiveness. Secondly, proteomic and histological analyses were conducted on formalin-fixed paraffin-embedded sections of liver metastases vs.
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