Disability rates for cardiovascular and psychological disorders among autoworkers by job category, facility type, and facility overtime hours.

Background: We examined the association between long work hours, assembly line work and stress-related diseases utilizing objective health and employment data from an employer's administrative databases.

Methods: A North American automobile manufacturing company provided data for claims for sickness, accident and disability insurance (work absence of at least 4 days) for cardiovascular disease (CVD), hypertension and psychological disorders, employee demographics, and facility hours worked per year for 1996-2001. Age-adjusted claim rates and age-adjusted rate ratios were calculated using Poisson regression, except for comparisons between production and skilled trades workers owing to lack of age denominator data by job category.

Effects of early mobilization on unhealed dysvascular transtibial amputation stumps: a clinical trial.

Objective: To observe the effects of early mobilization on unhealed transtibial (TT) amputation stump wounds of dysvascular etiology. An "unhealed" stump was defined as having a wound greater than 1cm x 1cm at least 3 weeks after surgery.

Design: An observational cohort study.

Highwire restrains synaptic growth by attenuating a MAP kinase signal.

Highwire is an extremely large, evolutionarily conserved E3 ubiquitin ligase that negatively regulates synaptic growth at the Drosophila NMJ. Highwire has been proposed to restrain synaptic growth by downregulating a synaptogenic signal. Here we identify such a downstream signaling pathway.

Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway.

Production of inositol hexakisphosphate (IP6) by Ipk1, the inositol-1,3,4,5,6-pentakisphosphate 2-kinase, is required for Gle1-mediated mRNA export in Saccharomyces cerevisiae cells. To examine the network of interactions that require IP6 production, an analysis of fitness defects was conducted in mutants harboring both an ipk1 null allele and a mutant allele in genes encoding nucleoporins or transport factors. Enhanced lethality was observed with a specific subset of mutants, including nup42, nup116, nup159, dbp5, and gle2, all of which had been previously connected to Gle1 function.

Evaluation of the clinical usefulness of isolation of fetal DNA from the maternal circulation.

Objective: To assess the reliability of isolating free fetal DNA from maternal usefulness.

Design: Fetal DNA was isolated from plasma or serum that was either collected prospectively or from archived samples collected for the purposes of second trimester screening.

Methods: Prospective samples were collected from patients undergoing prenatal diagnostic procedures (n = 24).

A patient-held record for cancer patients from diagnosis onwards.

This article presents the findings of a qualitative study looking at the content and use of a personally held record for cancer patients. The study was conducted in the York area of the UK over a 1-year period and the record was introduced to patients as near to diagnosis as possible. The record had three main sections: general information, communication sheets and a health diary.

Results of salmonella isolation from poultry products, poultry, poultry environment, and other characteristics.

Five hundred sixty-nine Salmonella were isolated out of 4745 samples from poultry products, poultry, and poultry environment in 1999 and 2000 from the Pacific northwest. These Salmonella were identified to their exact source, and some were serogrouped, serotyped, phage typed, and tested for antibiotic sensitivity. Food product samples tested included rinse water of spent hens and broilers and chicken ground meat.