Cancer among the circumpolar Inuit, 1989-2003. II. Patterns and trends.

Objectives: This is the second of 2 papers reporting on the result of the Circumpolar Inuit Cancer Review, an international collaborative effort involving researchers and health officials from Alaska, Canada and Greenland.

Methods: Inuit cancer cases by age-sex group and anatomic site were obtained from the regional cancer registries.

Results: Cancer in general is increasing among Inuit, in all regions, and among both men and women.

Cancer among the circumpolar Inuit, 1989-2003. I. Background and methods.

Objectives: This is first of 2 papers on the Circumpolar Inuit Cancer Review, an international collaborative effort involving researchers and health officials from Alaska, Canada and Greenland. It covers the period 1989-2003, updating the last review (1969-1988) and together provides an overview of the trends and patterns of cancer among the Inuit in 3 countries and over a 35-year period.

Methods: Inuit cancer cases by age-sex group and anatomic site were obtained from the regional cancer registries.

Human papillomavirus and cervical dysplasia in Nunavut: prelude to a screening strategy.

Objectives: To determine the prevalence of oncogenic human papillomavirus' (HPV) in Nunavut and to assess the association between HPV and squamous intraepithelial lesions (SIL) as a prelude to planning a better screening strategy.

Study Design: A cross-sectional study was conducted on the Pap-screened populations in 19 communities in Nunavut, Canada. SIL was determined using Liquid-based cytology, and HPV testing was done using the Hybrid Capture II assay.

Evaluation of a convenient enzyme immunoassay to assess the quality of genital specimens submitted for the detection of human papillomavirus DNA by consensus PCR.

Background: In the PGMY-line blot assay, a human beta-globin fragment is co-amplified with human papillomavirus (HPV) DNA, and both analytes are detected by hybridization with probes fixed on a strip in a linear array. The beta-globin DIG-MWP test also detects beta-globin amplicons, but in a microtiter plate-based enzyme immunoassay format. Although the PGMY-line blot assay detected 50 cells per test, the beta-globin DIG-MWP test generated a signal above the detection cut-off with five cells per test.