Publications by authors named "Sylvia Fernandez Boj"
Establishment of patient-derived adult stem cell-based pancreatic (tumor) organoids was first described in 2015. Since then, multiple laboratories have demonstrated the robustness of this method. We recently described the generation of a pancreatic cancer biobank containing 30 well-characterized tumor organoid models.
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- Breast cancer is made up of various subtypes with different genetic and clinical characteristics, which this study highlights by detailing a method for long-term culturing of human mammary epithelial organoids.
- Over 100 organoid lines were created from primary and metastatic breast cancer, effectively mirroring the original tumors' features like histopathology and hormone receptor status.
- The organoids were also shown to maintain genetic consistency and allow for drug testing that corresponds well with actual patient outcomes, making them valuable for cancer research and personalized treatment strategies.