The responsiveness of quality of life utilities to change in depression: a comparison of instruments (SF-6D, EQ-5D, and DFD).

Background: Utilities are often a main outcome parameter in economic evaluations. Because depression has a large influence on quality of life, it is expected that utilities are responsive to changes in depression.

Objective: To evaluate the change in utility derived from different instruments in depression, including the Short Form 6D (SF-6D), the Euroqol based on the UK (EQ-5D(UK)), the Euroqol based on the Dutch tariff (EQ-5D(NL)), and utilities derived from Beck Depression Inventory Second Edition (BDI-II) using the Depression-Free-Day method.

Discrepancy in rating health-related quality of life of depression between patient and general population.

Objective: To compare the quality of life valuation of a hypothetical depression health state between a general population versus a depressive patient population, and within a patient population.

Method: In a self-administered Internet questionnaire, both patient and general population groups filled in the Euroqol 5D (EQ-5D) questionnaire for a hypothetical depression health state describing mild (N = 740), moderate (N = 691), or severe (N = 670) depression and valued it using a rating scale (RS). The 'patient' group consisted of people reporting depressive complaints on the Internet questionnaire, subdivided into three depression severity groups (mild, moderate, severe) based on the Beck Depression Inventory Second Edition (BDI-II) and two groups according to self-perceived duration (≤ 3 months, ≥ 4 months) of depressive complaints (SPDD).

Use and acceptability of unsupported online computerized cognitive behavioral therapy for depression and associations with clinical outcome.

Background: In a recent randomized trial, we were unable to confirm the previously reported high effectiveness of CCBT. Therefore, the aim of the current study was to have a closer look at usage and acceptability (i.e.

Clinical and cost-effectiveness of computerised cognitive behavioural therapy for depression in primary care: design of a randomised trial.

Background: Major depression is a common mental health problem in the general population, associated with a substantial impact on quality of life and societal costs. However, many depressed patients in primary care do not receive the care they need. Reason for this is that pharmacotherapy is only effective in severely depressed patients and psychological treatments in primary care are scarce and costly.