Publications by authors named "Sylvette Nazario"

Article Synopsis
  • Black adults experience higher rates of asthma but are often studied as a uniform group, ignoring cultural differences among subgroups.
  • The study aimed to assess asthma-related health outcomes across various Black ethnic subgroups by comparing multiethnic Black (ME/B) and African American (AA/B) participants.
  • Results showed that ME/B participants had more emergency room visits and higher use of systemic corticosteroids for asthma than AA/B participants, particularly among Puerto Rican Black Latinx individuals.
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Objective: Influenza affects 5-15% of the worldwide population and is responsible for 4-5 million cases and 250,000-500,000 deaths. Despite established recommendations, vaccination rates continue to be low. Our study aimed to identify barriers to influenza immunization and attitudes toward the vaccine among respiratory health care (HC) professionals in Puerto Rico.

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Background: Black and Latinx adults experience disproportionate asthma-related morbidity and limited specialty care access. The severe acute respiratory syndrome coronavirus 2 pandemic expanded telehealth use.

Objective: To evaluate visit type (telehealth [TH] vs in-person [IP]) preferences and the impact of visit type on asthma outcomes among Black and Latinx adults with moderate-to-severe asthma.

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Article Synopsis
  • Black and Latinx adults with moderate-to-severe asthma were involved in a trial comparing a patient-activated inhaled glucocorticoid strategy (intervention) against usual care to address high asthma burdens in these populations.
  • The results showed that the intervention group experienced fewer severe asthma exacerbations (0.69 vs. 0.82) and improved asthma control over time compared to the usual-care group.
  • The intervention also led to a reduction in missed days due to asthma, enhancing participants' quality of life and indicating a potential benefit for tailored asthma management strategies in these communities.
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Asthma prevalence, morbidity, and mortality disproportionately impact African American/Black (AA/B) and Hispanic/Latinx (H/L) communities. Adherence to daily inhaled corticosteroid (ICS), recommended by asthma guidelines in all but the mildest cases of asthma, is generally poor. As-needed ICS has shown promise as a patient-empowering asthma management strategy, but it has not been rigorously studied in AA/B or H/L patients or in a real-world setting.

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Background: Underuse of guideline-recommended inhaled corticosteroids (ICS) controller therapy is a risk factor for greater asthma burden. ICS concomitantly used with rescue inhalers (Patient-Activated Reliever-Triggered ICS ['PARTICS']) reduced asthma exacerbations in efficacy trials, but whether PARTICS is effective in pragmatic trials is unknown.

Objective: We conducted this pilot to determine the feasibility of executing a large-scale pragmatic PARTICS trial and to improve study protocols.

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Intermittent tongue angioedema can be the initial presentation of several disorders including angiotensin-converting-enzyme inhibitor induced angioedema and hereditary angioedema. Persistent angioedema on the other hand, can be associated with amyloidosis, tumors, thyroid disorders and acromegaly. We present a case of intermittent episodes of tongue swelling progressing to macroglossia.

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Objective: The Asthma Control Test (ACT) questionnaire has been widely used and validated in various ethnic groups, showing an adequate correlation with physician assessment of asthma control. We sought to evaluate the relationship between ACT-defined asthma control and peak flow measures in subjects living in Puerto Rico.

Methods: A retrospective evaluation of data collected by a mobile asthma clinic in 2 cities in Puerto Rico was conducted.

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Objective: Anaphylaxis is a severe, potentially life-threatening systemic allergic reaction. Most cases of anaphylaxis are encountered and managed at Emergency Departments (ED). We aimed to evaluate all cases of anaphylaxis and of acute allergic reactions presenting to the ED of the Veterans Affairs Caribbean Healthcare System (VACHS) to assess each patient's presentation, the possible cause of that individual's allergic reaction or anaphylaxis, and the treatment or treatments that that person received.

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Objective: The people of Puerto Rico have one of the highest asthma prevalence and morbidity rates in the U.S.A.

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Introduction: Puerto Ricans have one of the highest asthma prevalence and morbidity rates. However, limited information is available on asthma care and attitudes toward asthma treatment among Puerto Ricans living in the island.

Methods: We evaluated a cohort of subjects attending Ambulatory Health Screen Clinic in the two main cities in the north and south of the island during August of 2008.

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Urticaria is a common disorder affecting approximately 15-25% of the population at some point in their life. We can assume that with the advancement of medical therapeutics, which have in turn prolonged the duration of life, the incidence of drug induced urticaria will increase in the geriatric population. Other common causes that need to be considered are allergy, autoimmune conditions and stress.

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Puerto Ricans have one of the highest asthma prevalence, morbidity and mortality in the world. Genetic, socioeconomic and environmental factors have been hypothesized to account for these elevated figures. The article discusses published articles on asthma among Puerto Ricans.

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Article Synopsis
  • This study aimed to confirm the link between the ORMDL3 gene and asthma by testing genetic variants in ethnically diverse groups, including Mexicans, Puerto Ricans, and African Americans.
  • Significant associations were found between two specific genetic variants (SNPs) within ORMDL3 and asthma in Mexican and African American populations, with some trends noted in Puerto Ricans.
  • While the findings support ORMDL3 as a risk factor for asthma, variability in results across different populations indicates more research is needed to understand how ORMDL3 influences asthma susceptibility.
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Socioeconomic and environmental differences do not fully explain differences in asthma prevalence, morbidity, and mortality among Puerto Ricans, African Americans, and Mexican Americans. Differences in response to albuterol may be a factor. We compared bronchodilator responsiveness between these three populations.

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Background: High levels of IgE are associated with asthma. Whether higher levels of IgE are associated with more severe asthma is still unclear.

Objective: To determine whether IgE is associated with asthma severity among Latino and African American subjects with asthma.

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Background: The prostanoid DP receptor (PTGDR) gene on chromosome 14q22.1 has been identified as an asthma susceptibility gene. A haplotype with decreased transcription factor binding and transcription efficiency was associated with decreased asthma susceptibility in African American and white subjects.

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