Publications by authors named "Sylvester J M Lim"
Article Synopsis
- The therapeutic potential of allosteric drugs is being recognized, but finding effective allosteric effectors has mostly been accidental rather than strategic.
- A new computational framework has been developed to systematically identify and design allosteric sites and effectors, enabling precise regulation of specific functional sites.
- This framework was validated with key proteins like the SARS-CoV-2 protease and K-Ras oncoprotein, showing potential for creating targeted allosteric therapies in the context of precision medicine.
Clostridium septicum infections are highly predictive of certain malignancies in human patients. To initiate infections, C. septicum spores must first germinate and regain vegetative growth.
View Article and Find Full Text PDFDevelopment of mass allelic exchange, a technique to enable sexual genetics in .
Proc Natl Acad Sci U S A
November 2022
Despite dramatic advances in genomics, connecting genotypes to phenotypes is still challenging. Sexual genetics combined with linkage analysis is a powerful solution to this problem but generally unavailable in bacteria. We build upon a strong negative selection system to invent mass allelic exchange (MAE), which enables hybridization of arbitrary (including pathogenic) strains of .
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