Comparison of immunoblotting (IgA and IgG) and the Goldmann-Witmer coefficient for diagnosis of ocular toxoplasmosis in immunocompetent patients.

Background: Ocular toxoplasmosis (OT) is a common cause of posterior uveitis worldwide. The diagnosis of OT is based on clinical findings, but in most cases, laboratory tests are required to confirm the aetiology, especially when other diseases are suspected. The aim of this study was to evaluate which methods, between the Goldmann-Witmer coefficient (GWC) and immunoblotting (IB) with both IgG and IgA, in aqueous humour (AH) samples, can be the most sensitive to diagnose OT, in current practice, especially in the first three weeks.

Biometric evaluation of anterior chamber changes after physiologic pupil dilation using Pentacam and anterior segment optical coherence tomography.

Purpose: We evaluated changes in anterior chamber (AC) morphology and iris volume induced by physiological mydriasis in fellow eyes of acute angle-closure patients, and age-, sex-, and central AC depth-matched primary angle-closure suspects (PACS).

Methods: In our study, 21 fellow eyes of patients with acute angle closure; 40 age-, sex-, and central AC depth-matched PACS eyes; and 40 age- and sex-matched normal open-angle eyes were imaged using a Pentacam and anterior segment optical coherence tomography (AS-OCT) under light conditions, and after 5 minutes of darkness using AS-OCT. Iris volume was estimated using AS-OCT and a customized image-processing software.

Biometric analysis of pigment dispersion syndrome using anterior segment optical coherence tomography.

Purpose: To compare anterior chamber volume (ACV), iris volume, and iridolenticular contact (ILC) area before and after laser peripheral iridotomy (LPI) in eyes with pigment dispersion syndrome (PDS) using anterior segment optical coherence tomography (AS OCT) and image processing software.

Design: Cross-sectional study.

Participants: Eighteen eyes of 18 patients with PDS; 30 eyes of 30 controls matched for age, gender, and refraction.

Structure-function relationships using spectral-domain optical coherence tomography: comparison with scanning laser polarimetry.

Purpose: To evaluate and compare the regional relationships between visual field sensitivity and retinal nerve fiber layer (RNFL) thickness as measured by spectral-domain optical coherence tomography (OCT) and scanning laser polarimetry.

Design: Prospective cross-sectional study.

Methods: One hundred and twenty eyes of 120 patients (40 with healthy eyes, 40 with suspected glaucoma, and 40 with glaucoma) were tested on Cirrus-OCT, GDx VCC, and standard automated perimetry.