Expression of DOG1 (Using SP31) in Poorly Differentiated Carcinoma of the Head and Neck.

Background: The calcium-activated chloride channel protein discovered on gastrointestinal stromal tumour 1 (DOG1) is expressed in a variety of normal and neoplastic tissues. DOG1 is a specific marker for gastrointestinal stromal tumour. In the head and neck region, DOG1 is a sensitive discriminator for acinar cell carcinoma.

Congenital Auricular Malformations: Description of Anomalies and Syndromes.

Half of the malformations in the ear, nose, and throat region affect the ear. Malformations of the external ear (pinna or auricle with external auditory canal [EAC]) are collectively termed microtia. Microtia is a congenital anomaly that ranges in severity from mild structural abnormalities to complete absence of the external ear (anotia).

Expression of podoplanin in primary and metastatic poorly differentiated and undifferentiated carcinomas of the head and neck.

Unlabelled: The invasive growth properties of head and neck carcinoma can be determined by proteins associated with cellular motility. Podoplanin is a recently identified protein associated with motility of cells.

Materials And Methods: Sixty-five tumour specimens of 51 patients with poorly and undifferentiated carcinomas were investigated for podoplanin expression.

Vascular endothelial growth factor (VEGF) in sera of oral and oropharyngeal squamous cell carcinoma patients.

This study was performed to investigate the serum levels of vascular endothelial growth factor (VEGF) in patients with oral and oropharyngeal cancer. The study population included 86 patients with untreated cancer of this region. VEGF serum levels varied considerably and showed no correlation to tumour size or locoregional spread.

Insulin-like growth factor-1 receptor (IGF-1R) in primary and metastatic undifferentiated carcinoma of the head and neck: a possible target of immunotherapy.

Background: Insulin-like growth-factor 1 receptor (IGF-1R) plays a key role in the development of cancer and is important for the regulation of tissue growth, predominantly via the growth hormone (GH). Targeting IGF-1R is a current topic of cancer research. The aim of this study was to identify IGF-1R in undifferentiated carcinomas of the head and neck.

Morphometrics of the facial nerve following fractionated external irradiation: an experimental study in rats.

Unlabelled: This study provides morphometric data on radiation-induced alterations of the facial nerve in female Wistar rats. The facial nerves were explanted 3 to 4 or 7 to 9 months after completion of a fractionated external irradiation of the left side of the neck (5 days per week, 6 weeks, total: 60 Gray). Both facial nerves were investigated in order to identify possible effects of scattered irradiation on them.

Expression of neuron-specific enolase in irradiated salivary glands of the rat: a pilot study.

External irradiation of advanced head and neck cancer often includes the major salivary glands, despite them not being affected by the disease. The aim of this study was to determine neuron-specific enolase (NSE) as a marker of inflammation in irradiated and non-irradiated salivary glands of the rat. This study shows that NSE expression in irradiated salivary glands is dependent on the topography of the organ related to the irradiation source.

Immunohistochemical study on an epithelial-myoepithelial intercalated duct carcinoma transplanted to the nude mouse.

Parotid gland carcinomas are rare. Among them, the epithelial-myoepithelial carcinoma (EMC) is extremely rarely diagnosed. This case report was based on a female with a history of 17 years of recurrent EMC of the parotid and evidence of distant metastasis over a period of 2 years.

Development of fMRI tests for children with central auditory processing disorders.

The term 'central auditory processing disorder' (CAPD; in German-speaking countries: 'auditive Verarbeitungs- und Wahrnehmungsstörung', AVWS) embraces various complex disorders of central auditory function. The purpose of this preliminary study was to develop a functional magnetic resonance imaging (fMRI) test set in order to extend the diagnostic work-up to include imaging, and thus to improve both diagnostic performance and the monitoring of treatment outcome. fMRI was performed in 11 healthy children ranging in age from 7 to 10 years and in 11 healthy adults (age range: 23 to 31 years).

Rapidly progressive and metastatic mucoepidermoid carcinoma: application of serological tumor markers.

Mucoepidermoid carcinoma (MEC) of the salivary gland is a rare entity. A distinction of 2 variants has been proposed: the low-grade tumor with a favourable prognosis and the high-grade tumor with a poor prognosis. Indeed, MEC is a cancer with a relative favourable outcome and more than 90% of patients survive for more than 5 years after diagnosis, reduced to about 70% after 10 years.

Classification and diagnosis of ear malformations.

In the ENT region 50% of the malformations affect the ear. Malformations of the outer and middle ear are predominantly unilateral (ca. 70-90%) and mostly involve the right ear.

Duplication of Xq26.2-q27.1, including SOX3, in a mother and daughter with short stature and dyslalia.

Duplications of the distal long arm of the X chromosome are rare and carrier females are usually phenotypically normal. We report on a 14-year-old short statured (height and weight <3rd centile) girl with dup(X)(q26.2q27.

Epstein-Barr virus DNA and epithelial markers in nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC) belongs to the most common malignant tumours in certain parts of the world, e.g. South-East Asia.

The effect of external fractionated irradiation on the distribution pattern of extracellular matrix proteins in submandibular salivary glands of the rat.

Introduction: The aim of this study was to analyse the distribution pattern of extracellular matrix proteins in the irradiated and non-irradiated rat submandibular salivary gland in order to provide a more detailed profile of the radiation injury following radiotherapy of the head and neck.

Material And Methods: External X-ray exposure, restricted to the left skull base and neck region, was performed in 60 female Wistar rats, fractionated to daily applications of 2 Gy, up to total dosages of 20, 40 or 60 Gy. Both submandibular glands were excised after supravital anaesthesia 6 months or 1 year after completion of the irradiation.