BubR1 Controls Heart Development by Promoting Expression of Cardiogenesis Regulators.

Background: Congenital heart defects are structural anomalies present at birth that can affect the function of the heart. Aneuploidy is a significant risk factor for congenital heart defects. Mosaic variegated aneuploidy syndrome, caused by mutations in (encoding BubR1, a mitotic checkpoint protein), leads to congenital heart defects such as septal defects.