Immunomodulatory drugs (IMiDs) like CC-4047 can help the immune system by boosting the production of a protein called IL-2 in T cells while reducing another substance called TNF-alpha.
The study found that CC-4047 not only increases IL-2 levels but also changes how certain proteins, known as transcription factors, work in T cells, especially enhancing one called AP-1.
With higher IL-2 levels, natural killer (NK) cells get activated, which helps them fight off harmful cells like cancer cells.