Investigating the effect of vandetanib and celecoxib combination on angiogenesis.

Objective: Angiogenesis plays an important role in various physiological and pathological conditions and is essential for tumor growth and metastasis. The aim of this study was to evaluate the effect of a combination of vandetanib and celecoxib on angiogenic tube formation and its effect on angiogenic genes (MMP-2 and MMP-9) using an model of human umbilical vein endothelial cells (HUVECs).

Methods: HUVECs were cultured and verified by flow cytometry.

Comparison of efficacy and safety of topiramate with gabapentin in migraine prophylaxis: randomized open label control trial.

Objective: To compare the efficacy and safety of topiramate with gabapentin in the prophylaxis of migraine patients.

Methods: A 12-week randomised open label control trial was conducted at the Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre (JPMC), Karachi from January to March 2011 involving 80 outpatients who had a history of migraine. The sample was divided into two equal groups.