Psycho-social sufferings and sexual difficulties among female survivors of child sexual abuse in Pakistan.

Background: Child sexual abuse is a universal social challenge and the victims of childhood sexual abuse suffer a range of short and long term psychological, social, behavioral and physical problems that vary in different cultures. The study was carried out to explore the perceived impacts of childhood sexual abuse in Pakistan, because no such study was conducted in Pakistan earlier.

Methods: Interpretative phenomenological analysis was used to analyze the data.

Effect of stress urinary incontinence on vaginal microbial communities.

Background: Postpartum women often experience stress urinary incontinence (SUI) and vaginal microbial dysbiosis, which seriously affect women's physical and mental health. Understanding the relationship between SUI and vaginal microbiota composition may help to prevent vaginal diseases, but research on the potential association between these conditions is limited.

Results: This study employed 16S rRNA gene sequencing to explore the association between SUI and vaginal dysbiosis.

Biopsychosocial determinant of quality of life of older adults in Pakistan and Canada.

Background: The rapidly rising average age of the older adults has brought various global healthcare challenges. A core challenge is how to enhance their quality of life (QoL).

Objective: The objective of the current study was to test the significance of biopsychosocial determinants of quality of life of older adults in Pakistan and Canada.

Tailoring BiSe Topological Insulator for Visible-NIR Photodetectors with Schottky Contacts Using Liquid Phase Exfoliation.

Layered semiconductors of the V-VI group have attracted considerable attention in optoelectronic applications owing to their atomically thin structures. They offer thickness-dependent optical and electronic properties, promising ultrafast response time, and high sensitivity. Compared to the bulk, 2D bismuth selenide (BiSe) is recently considered a highly promising material.

Psychometric evaluation and validation of Urdu Social Rank Scale for women with infertility in Pakistan.

Background: Infertility negatively affects nearly all aspects of women's life and is a source of demotion in the rank/status of women that they have achieved after marriage. This social rank/status demotion due to infertility may result in depression and several other psychopathologies. No extant instrument is available to measure the phenomenon of social rank in women with infertility in Pakistan.

Clinical and Genetic Description of Hereditary Chronic Pancreatitis in Pakistani Children.

Background/aims: The purpose of this study was to identify the spectrum and frequency of pathogenic variants as well as the clinical and genetic insight of hereditary chronic pancreatitis in Pakistani children.

Materials And Methods: The deoxyribonucleic acid of affected probands of 44 unrelated Pakistani families, having hereditary chronic pancreatitis-affected children, were subjected to massive parallel sequencing for candidate reported genes (SPINK1, PRSS1, CFTR, CPA1, CTRC, CBS, AGL, PHKB, and LPL). Data were analyzed using different bioinformatics tools for the variants and in-silico analysis.

Enzymatic properties of alcohol dehydrogenase PedE_M.s. derived from sp. M107 and its broad metal selectivity.

As an important metabolic enzyme in methylotrophs, pyrroloquinoline quinone (PQQ)-dependent alcohol dehydrogenases play significant roles in the global carbon and nitrogen cycles. In this article, a calcium (Ca)-dependent alcohol dehydrogenase PedE_M.s.

Impact of bacterial synthesized nanoparticles on quality attributes and postharvest disease control efficacy of apricot and loquat.

Postharvest fungal attacks on fruits such as apricots and loquats are common. Diseased fruit samples were collected from Murree's local fruit markets. The disease-causing pathogens were identified utilizing molecular, microscopic, and morphological characteristics.

Advances in new target molecules against schistosomiasis: A comprehensive discussion of physiological structure and nutrient intake.

Schistosomiasis, a severe parasitic disease, is primarily caused by Schistosoma mansoni, Schistosoma japonicum, or Schistosoma haematobium. Currently, praziquantel is the only recommended drug for human schistosome infection. However, the lack of efficacy of praziquantel against juvenile worms and concerns about the emergence of drug resistance are driving forces behind the research for an alternative medication.

alleviates the pathological injuries in mice infected with by modulating intestinal microbiome.

causes serious pathological organ damage and alteration of the intestinal microbiome in the mammalian host, threatening the health of millions of people in China. has been reported to be able to alleviate the damage to the gut and liver and maintain the homeostasis of the intestinal microenvironment. However, it was unclear whether could alleviate the hepatic and intestinal symptoms caused by .

Unveiling Frequently Co-Occurring Reasons of Attitudinal Acceptance of Intimate Partner Violence against Women: A Behavioral Data Science Perspective.

The results of gender equality indicators across the world in the form of prevalence of intimate partner violence (IPV) against women are striking and has thus drawn the attention of policy makers as well as necessitates the adoption of a comprehensive system to deal with. The situation of IPV in Pakistan is alarming. This study examines the acceptability attitude of women and men toward intimate partner violence against women through data science.

Lamotrigine-associated haemophagocytic lymphohistiocytosis (HLH) confounded with underlying rheumatoid arthritis.

Haemophagocytic lymphohistiocytosis (HLH) is one of the rare haematological syndromes more commonly reported in infants/children than adults. This disease is known for its aggressive dysregulated immune response affecting the host rapidly, causing multiorgan dysfunction and thus carries a high mortality. The disease still remains cryptic in this current decade despite all the developments in the ever-evolving field of haematology.

Very early onset inflammatory bowel disease: Spectrum of clinical presentation, diagnostic tools and outcome in children.

Objective: To explore the spectrum of presentation, underlying monogenetic defects and outcome in very early onset inflammatory bowel disease (VEO-IBD).

Method: The prospective, observational study was conducted at the Children's Hospital, Lahore, Pakistan, from January 2017 to December 2018, and comprised children developing features of inflammatory bowel disease aged <6 years. Data included demography, clinical presentation, diagnostic tools and outcome.

Intrahepatic cholestasis of pregnancy in conjunction with a frameshift deletion in FGFR4.

Intrahepatic cholestasis of pregnancy (ICP) is characterized by increased serum bile acid levels in the third trimester of pregnancy and resolves quickly after delivery. Here, we present the case of a 29-year-old woman who developed idiopathic liver damage during puberty, and subsequently ICP and severe pruritus during two pregnancies. DNA sequencing revealed a heterozygous deletion (c.

Tailoring the bandgap of MnO for visible light driven photocatalysis.

The photocatalytic activity of pure MnO and silver (Ag) modified MnO nanoparticles have been investigated. The nanoparticles were prepared by using co-precipitation technique. The structural analysis showed that the Ag modified MnO was successfully synthesized.

A systematic review and meta-analysis of impact of baseline thrombocytopenia on cardiovascular outcomes and mortality in patients undergoing percutaneous coronary intervention.

Background: Thrombocytopenia (TP) is associated with higher incidence of bleeding in the setting of percutaneous coronary intervention (PCI) leading to increased morbidity and mortality. Herein, we report a meta-analysis evaluating the effects of baseline thrombocytopenia (bTP) on cardiovascular outcomes in patients undergoing PCI.

Methods: Literature search was performed using PubMed, Embase, Cochrane library and clinicaltrials.

Process of career identity formation among adolescents: components and factors.

To qualitatively explore the process and factors that influence career identity formation, data were collected from 18 middle adolescents of age ranged between 15 and 17 years. Thematic analysis revealed that the process of career identity comprised exploration, commitment, and reconsideration components. Eight factors (viz.

Obstructive sleep apnea and peripheral vascular disease: a systematic review based on current literature.

Introduction: Obstructive sleep apnea (OSA) is an established risk factor for poor cardiovascular outcomes and coronary artery disease, but its influence on the development of peripheral artery disease (PAD) is not well established. The aim of our study was to understand the mutual prevalence of OSA and PAD and any reported statistical association between the two conditions.

Methods: PubMed, Ovid Embase, Web of Science, Cochrane library and clinicaltrials.

Impact of Acquired Thrombocytopenia on Cardiovascular Outcomes in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

Background: Acquired thrombocytopenia (aTP) is associated with a high frequency of bleeding and ischemic complications in patients undergoing percutaneous coronary intervention (PCI). Herein, we report a meta-analysis evaluating the adverse effects of aTP on cardiovascular outcomes and mortality post-PCI.

Methods: A literature search was performed using PubMed, Embase, Cochrane and, clinicaltrials.

Zinner Syndrome Unmasked by Workup for Renal Colic and Uncontrolled Hypertension.

Zinner syndrome is a rare hereditary disorder of the mesonephric duct. The triad of the absence of one kidney, ipsilateral cystic dilatation of the seminal vesicle, and ejaculatory duct obstruction makes the diagnosis. Mostly, it is asymptomatic.

Miscarriage: Emotional burden and social suffering for women in Pakistan.

The study aimed to explore the bereavement experiences of women after miscarriage. Ten women who experienced miscarriages of their first child were interviewed. Verbatim interviews were analyzed through the principles of Interpretative Phenomenological Analysis that yielded eight super ordinate themes: shattered planning; physical and emotional pain; reaction to miscarriage; transformed marital relationships; in-laws' support; blame attribution; identity and well-being; and posttraumatic growth.

Construction and Validation of Afterlife Belief Scale for Muslims.

The purpose of this study was to develop a scale in Urdu language for measuring different dimensions of afterlife belief. The scale was subjected to exploratory and confirmatory factor analysis on a sample of 504 individuals (235 men and 269 women) recruited from different cities in the Punjab, Pakistan. After exploratory and confirmatory factor analysis, 16 items were retained with three well-defined factor structures of afterlife belief: positive, negative, and extinction.

Urdu Translation and Validation of Short Muslim Practice and Belief Scale in Pakistan.

The present study was conducted to translate and validate the Short Muslim Practice and Belief Scale (SMPBS) (AlMarri, Oei, & Al-Adawi, 2009) to have a culturally equivalent and linguistically accurate Urdu version for use in Pakistan. Forward backward translation method was used for translation followed by tryout of the scale. Urdu translated version of the scale was completed by 500 participants of different age groups (M = 36.