Evidence-based risk stratification of myeloid neoplasms harboring TP53 mutations.

This retrospective analysis aimed to provide evidence-based risk-stratification of TP53-mutated (TP53mut) myeloid neoplasms (MN). Of 580 MN harboring TP53mut with variant allele frequency (VAF) ≥2%, 219 (37.8%), 194 (33.

Exogenous sex steroid hormones and asthma phenotypes: a study protocol for a prospective cohort analysis with UK-wide primary care data.

Introduction: The role of female sex hormones and their influence on asthma's development and natural history remain uncertain. Our study aims to enhance understanding of exogenous sex hormones' role in asthma development and manifestation, considering phenotypic heterogeneity and focusing on metabolic syndrome-linked asthma that has shown increased severity in females.

Methods And Analysis: A cohort study using primary care data from the Clinical Practice Research Datalink (CPRD) databases linked with additional data sources (Hospital Episode Statistics, ethnicity and deprivation) will include individuals aged 16-70 years, spanning 1 January 2005 to 31 December 2019.

Association of family history of cardiovascular disease with the prevalence of cardiometabolic risk factors in young adults in the United Arab Emirates: The UAE healthy future study.

Introduction: Family history of cardiovascular disease (CVD) is an independent risk factor for coronary heart disease, and the risk increases with number of family members affected. It offers insights into shared genetic, environmental and lifestyle factors that influence heart disease risk. In this study, we aimed to estimate the association of family history of CVD and its risk factors, as well as the number of affected parents or siblings, with the prevalence of major cardiometabolic risk factors (CRFs) such as hypertension, dysglycemia, dyslipidemia and obesity in a sample of young adults.

MOF-Based Electrocatalysts: An Overview from the Perspective of Structural Design.

The electrocatalytic technique, as an efficient energy storage and conversion technology, has attracted significant attention to address energy exhaustion and environmental pollution. Usually, the activity and selectivity of electrocatalytic reactions are largely dominated by the dynamic process occurring on electrocatalysts. Therefore, high-performance electrocatalysts, which can dominate the pathway and energy barrier of reactions, are of great significance for the advancement of the electrocatalytic technique.

Integrating local and global attention mechanisms for enhanced oral cancer detection and explainability.

Background And Objective: Early detection of Oral Squamous Cell Carcinoma (OSCC) improves survival rates, but traditional diagnostic methods often produce inconsistent results. This study introduces the Oral Cancer Attention Network (OCANet), a U-Net-based architecture designed to enhance tumor segmentation in hematoxylin and eosin (H&E)-stained images. By integrating local and global attention mechanisms, OCANet captures complex cancerous patterns that existing deep-learning models may overlook.

Evaluating Drug-Eluting Balloons Versus Stenting for Provisional Bifurcation Lesions: Short-Term Outcomes and Future Directions.

Background This prospective cohort study aimed to evaluate the short-term clinical outcomes of drug-eluting balloons (DEBs) versus stenting in provisional bifurcation lesions, focusing on procedural success, safety, and major adverse cardiac events (MACE). The study specifically assessed key adverse outcomes, including restenosis, target lesion revascularization (TLR), myocardial infarction (MI), stent thrombosis, and mortality. Bifurcation lesions present significant challenges in interventional cardiology due to their complex anatomy, which contributes to a higher risk of restenosis, side-branch occlusion, and thrombotic events.

LLM-based kidney disease diagnostic framework for Pathologists.

Large language models revolutionize the recent paradigm in the medical field and its contributing to various applications, diversified from clinical decision support to information extraction and summarization. The substantial linguistic understanding and contextual awareness allow language models to process and evaluate decision tasks. Concurrently, it addresses the challenges encountered by pathologists in disease diagnosis by adeptly retrieving precise and accurate facts from an external knowledge base.

Gen-17, a beta-methyl derivative of Genipin, attenuates LPS-induced ALI by regulating Keap1-Nrf2/HO-1 and suppressing NF-κB and MAPK-dependent signaling pathways.

Background And Objective: Acute lung injury (ALI) represents a complicated and debilitating pulmonary disorder for which therapeutic options are currently limited. Genipin is an aglycone derived from the geniposide, the most abundant iridoid glucoside constituent of Gardenia jasminoides Ellis, and has demonstrated beneficial effects in ALI. The objective of this study was to investigate the protective effect of Gen-17, a beta-methyl derivative of genipin, against ALI in vitro and in vivo, and explore its mechanism of action.

New hydroxylated metabolite derived from the microbial biotransformation of 11α-acetoxyprogesterone by the endophytic fungus Phyllosticta sp. 16L1 and its cytotoxic activity.

Biotransformations catalysed by microbes are promising approach for producing a vast library of structurally diverse chemical molecules with applications in the pharmaceutical industry. The biotransformation of 11α-acetoxyprogesterone (1) by Phyllosticta sp. 16L1 has not been previously reported.

The key challenges and best alternatives to environmental sustainability: a comprehensive study.

In the modern world, the globe has been trapped by severe challenges, and an abrupt increase in environmental deterioration (ED) is one of these. The practitioners have recently tried to suggest several green initiatives to combat rising environmental concerns, but the problem remains intact. Most economies have priorities to meet their socio-economic target, and practitioners are unaware of true challenges and best alternatives.

Ameliorating Nickel-Induced Stress in Hypophthalmichthys molitrix (Silver Carp) Through Piper nigrum Extract Supplementation.

The current study examined the damaging implications of nickel (Ni) toxicity on body composition, growth responses, histology and hematology of Hypophthalmichthys molitrix, as well as the potential mitigating effects of Piper nigrum extract. For this purpose, H. molitrix were distributed into six groups, namely T1, T2, T3, T4, T5, and T6.

Efficacy of drug-coated balloon versus uncoated balloon for dysfunctional dialysis access: a systematic review and meta-analysis.

Background: Dysfunctional vascular access is a major cause of morbidity and mortality in patients undergoing hemodialysis, affecting both arteriovenous fistulas and grafts. The most optimal strategy to restore long-term patency has not been established. This meta-analysis compares drug-coated balloon (DCB) versus uncoated balloon (UCB) angioplasty for dysfunctional vascular access.

Explainable AI-driven prediction of APE1 inhibitors: enhancing cancer therapy with machine learning models and feature importance analysis.

The viability of cells and the integrity of the genome depend on the detection and repair of damaged DNA through intricate mechanisms. Cancer treatment employs chemotherapy or radiation therapy to eliminate neoplastic cells by causing substantial damage to their DNA. In many cases, improved DNA repair mechanisms lead to resistance to these medicines; therefore, it is essential to expand efforts to develop drugs that can sensitise cells to these treatments by inhibiting the DNA repair process.

and gastric cancer: current insights and nanoparticle-based interventions.

: is recognized as one of the main causes of gastric cancer, and this type of cancer is considered as one of the leading diseases causing cancer deaths all over the world. Knowledge on the interactions between and gastric carcinogenesis is important for designing preventive measures. : the objective of this review is to summarize the available literature on and gastric cancer, specifically regarding the molecular mechanisms, nanoparticle-based therapy and clinical developments.

Evaluating the Safety and Efficacy of Ticagrelor vs. Clopidogrel Following Percutaneous Coronary Intervention in Chronic Coronary Disease.

Objective This study aimed to compare the safety and efficacy of ticagrelor and clopidogrel in reducing major adverse cardiovascular events (MACE) among patients undergoing percutaneous coronary intervention (PCI) for chronic coronary disease. Additionally, secondary endpoints, including adverse events such as major bleeding, minor bleeding, and dyspnea, were assessed to evaluate the overall safety profile of both antiplatelet therapies. Methodology A prospective cohort study was conducted at Kuwait Teaching Hospital, Peshawar, Pakistan, enrolling 300 patients (150 receiving ticagrelor and 150 receiving clopidogrel) from July 2023 to June 2024.

In-silico Study of an Inhibitor of S-Adenosyl-L-Homocysteine Hydrolase (SAHH) of Naegleria fowleri using Molecular Docking, Density Functional Theory (DFT), and Molecular Dynamics (MD) Simulation.

Naegleria fowleri causes primary amoebic meningoencephalitis (PAM), a lethal disease with a mortality rate of 97%. Current treatment options are limited and often ineffective, highlighting the urgent need for novel therapeutic agents. This study aimed to identify potential inhibitors of the S-adenosyl-L-homocysteine hydrolase (SAHH) enzyme from N.

Nanosensor for the detection of bromothymol blue dye and its removal from wastewater by sustainable methods.

This study introduces the environmentally friendly synthesis of AgO, TiO, and Ni-doped SnO nanoparticles (NPs) and their application in detecting and removing bromothymol blue (BTB) dye from wastewater. The unique electronic properties and quantum size effects of NPs allow them to surpass conventional materials. Characterization of the synthesized nanoparticles was conducted through spectroscopic and voltammetric techniques.

Effect of Carbon Nanomaterials Incorporated Polymeric Membrane Separators for Energy Storage Devices.

The rapid expansion of the global population and technological advancements have heightened the need for efficient energy conversion and electrochemical energy storage. Electrochemical energy systems like batteries and supercapacitors have seen notable development to meet this demand. However, conventional polymeric membrane separators in these systems face challenges due to limited porosity and poor mechanical and thermal properties, reducing overall electrochemical performance.

Enhancing multimodal medical image analysis with Slice-Fusion: A novel fusion approach to address modality imbalance.

Background And Objective: In recent times, medical imaging analysis (MIA) has seen an increasing interest due to its core application in computer-aided diagnosis systems (CADs). A modality in MIA refers to a specific technology used to produce human body images, such as MRI, CT scans, or X-rays. Each modality presents unique challenges and characteristics, often leading to imbalances within datasets.

Differential gene expression analysis and machine learning identified structural, TFs, cytokine and glycoproteins, including SOX2, TOP2A, SPP1, COL1A1, and TIMP1 as potential drivers of lung cancer.

Background: Lung cancer is a primary global health concern, responsible for a considerable portion of cancer-related fatalities worldwide. Understanding its molecular complexities is crucial for identifying potential targets for treatment. The goal is to slow disease progression and intervene early to prevent the development of advanced lung cancer cases.

Efficient photocatalytic degradation of bisphenol A on 2D-3D spherically hierarchical structure ZnInS.

Bisphenol A (BPA) poses a significant environmental threat due to its widespread use as an industrial chemical and its classification as an environmental endocrine disruptor. The urgent need for effective BPA removal has driven research toward innovative solutions. In this study, we present the synthesis and application of a novel 2D-3D spherically hierarchical ZnInS (ZIS) photocatalyst for the photocatalytic degradation of BPA under visible light for the first time.

Copper(II) complexes of 2-hydroxy-1-naphthaldehyde Schiff bases: synthesis, activity and computational studies.

Background: Due to the divers biological applications of Cu(II) complexes, we in this study reports the various Cu(II) complexes. The study aims to synthesize and assess new Cu(II) complexes as powerful β-glucuronidase inhibitors.

Methods: Five Schiff base ligands and their complexes were synthesized, characterized, and screened against β-glucuronidase inhibitory activity.

Association of BCHE gene SNP rs1803274 (K-variant) and rs3495 with obesity in Pakistani population group.

Background: Obesity plays a crucial role in the development of metabolic disorders including diabetes, coronary and renal diseases. There are several factors involved in the pathology of obesity, including chronic inflammation and exposure to environmental contaminants. Recently, the cholinergic co-hydrolyzing enzyme BChE has been associated with clinical conditions such as diabetes and obesity.

CARDBiomedBench: A Benchmark for Evaluating Large Language Model Performance in Biomedical Research: A novel question-and-answer benchmark designed to assess Large Language Models' comprehension of biomedical research, piloted on Neurodegenerative Diseases.

Backgrounds: Biomedical research requires sophisticated understanding and reasoning across multiple specializations. While large language models (LLMs) show promise in scientific applications, their capability to safely and accurately support complex biomedical research remains uncertain.

Methods: We present , a novel question-and-answer benchmark for evaluating LLMs in biomedical research.

CD58 expression does not impact response to inotuzumab ozogamicin in patients with B-cell acute lymphoblastic leukemia.

Background: CD58 loss has been described as a mechanism of resistance to blinatumomab and chimeric antigen receptor T-cell therapy, functioning as a modulator of response to T-cell activation.

Methods: Using flow cytometry, we evaluated the impact of CD58 mean fluorescence intensity (MFI) on the probability of achieving measurable residual disease (MRD) negativity in patients with B-cell acute lymphoblastic leukemia treated with inotuzumab ozogamicin (InO).

Results: The odds ratio of achieving MRD negativity was 1.