Publications by authors named "Syed Muhammad Sinaan Ali"
Purpose: Patients with heart failure and concomitant renal impairment are often prescribed loop diuretics, such as furosemide, as the primary treatment. The present meta-analysis is focused on analyzing the safety and efficacy of the implementation of tolvaptan as a novel approach in patients with renal impairment and heart failure.
Methods: Two reviewers conducted a screening of articles using online databases, including PubMed, Google Scholar, and Embase.
Article Synopsis
- Malignant neoplasms of bone and articular cartilage, though rare, significantly impact health with rising mortality rates, requiring focused interventions to enhance patient outcomes.
- A retrospective study analyzed CDC WONDER data on mortality rates among adults aged 65 and older from 1999 to 2020, revealing an initial decline in age-adjusted mortality rates until 2012, followed by a sharp increase.
- The study found higher mortality rates among men and NH Black individuals, particularly in Southern states and nonmetropolitan areas, indicating a pressing need for targeted public health strategies to address these disparities.
Comparing DCE-MRI and DSA: Understanding the embolization of hypervascular spinal metastases.
J Med Imaging Radiat Oncol
November 2024
This study aims to examine and compare the effectiveness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and Digital Subtraction Angiography (DSA) in evaluating hypervascular spinal metastases. A comprehensive literature review was conducted, utilizing top-tier databases such as PubMed, Scopus and Google Scholar, to compile an authoritative and up-to-date overview of the current advancements in the field. We synthesized key studies focusing on the advantages, limitations and efficacy of both imaging techniques.
View Article and Find Full Text PDFEvaluating efficacy and safety of laser interstitial thermal therapy in patients with newly diagnosed and recurrent glioblastoma: a systematic review and meta-analysis.
Neurosurg Rev
November 2024
Glioblastoma (GB), the most common malignant brain tumour, has a poor prognosis despite advances in treatment. Standard management involves surgery followed by chemoradiotherapy. MRI-guided laser interstitial thermal therapy (LITT) is a minimally invasive technique that may offer an option for select patients with specific clinical profiles.
View Article and Find Full Text PDFBackground And Objective: Pancreatic cancer (PC) is a significant cause of cancer-related mortality, with limited curative options and high rates of cachexia, a debilitating syndrome associated with poor prognosis. While previous research has linked sarcopenia to poor outcomes in PC, the correlation between cachexia and treatment outcomes remains underexplored. This meta-analysis aims to investigate the association between cachexia and overall survival and time to treatment failure in advanced PC patients undergoing first-line chemotherapy.
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- Chronic migraine significantly affects young women and has major societal impacts; this study evaluates the effectiveness of Greater Occipital Nerve Block (GONB) using local anesthetics versus a placebo.
- A systematic review and meta-analysis of relevant studies found that GONB led to a notable decrease in headache intensity and frequency within the first two months, with no significant increase in adverse events compared to the placebo group.
- The study concludes that while GONB is safe and effective, more extensive research is needed to confirm results and explore different treatment options for chronic migraine management.
Background: Appendicitis is a common surgical emergency with diverse clinical presentations, making its diagnosis challenging. Laparoscopic appendectomy has become the standard treatment, with various methods for appendiceal stump closure, including polymeric clips and endoloops. This study aims to compare the efficacy and safety of polymeric clips compared with endoloops in laparoscopic appendectomy.
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- - Protein C deficiency is a rare genetic disorder linked to blood clotting issues, affecting about 1 in 200-500 people, leading to an increased risk of conditions like deep vein thrombosis and pulmonary embolism.
- - A case study highlighted a 21-year-old male showing severe symptoms such as fever and leg pain, ultimately diagnosed with the disorder after confirming multiple blood clots.
- - Treatment involves anticoagulant therapies, and in severe cases, may require procedures like an inferior vena cava filter, emphasizing the importance of early diagnosis and management to prevent serious complications.
Objective: Acute subdural hematoma (ASDH) stands as a significant contributor to morbidity after severe traumatic brain injuries (TBI). The primary treatment approach for patients experiencing progressive neurological deficits or notable mass effects is the surgical removal of the hematoma, which can be achieved through craniotomy (CO) or decompressive craniectomy (DC). Nevertheless, the choice between these two procedures remains a subject of ongoing debate and controversy.
View Article and Find Full Text PDFThe ketogenic diet (KD), characterized by high-fat and low-carbohydrate intake, is currently gaining widespread popularity as a treatment for drug-resistant epilepsy (DRE). In addition to the traditional ketogenic diet, several variants have been introduced to enhance compliance and flexibility, such as the modified Atkins diet (MAD) and the low glycemic index diet (LGID). These adaptations aim to provide patients with more manageable and sustainable options while harnessing the potential therapeutic benefits of DRE.
View Article and Find Full Text PDFBackground: Chronic subdural hematoma (CSDH) is a condition characterized by the accumulation of fluid, blood, and blood breakdown products between the brain's arachnoid and dura mater coverings. While steroids have been explored as a potential treatment option, their efficacy and safety remain uncertain. This meta-analysis and systematic review aimed to assess the impact of steroids on CSDH management, including mortality, recurrence, complications, and functional outcomes.
View Article and Find Full Text PDFBackground: Debates persist when using intravenous thrombolysis (IVT) before mechanical thrombectomy (MT) for acute ischemic stroke (AIS) due to large-vessel occlusion (LVO). This systematic review and meta-analysis synthesized evidence on outcomes in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO), comparing bridging therapy (BT) with MT alone.
Method: We conducted searches of PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials from inception to July 2023 to identify pertinent clinical trials and observational studies.
Purpose: To learn more about the effectiveness of oral propranolol as a therapeutic alternative for preterm newborns with pre-existing retinopathy of prematurity (ROP) as well as an early prevention method for ROP, one of the most common but avoidable causes of juvenile blindness.
Study Design: Meta-analysis of relevant literature.
Methods: A total of 3464 papers were identified, with 2873 from PubMed, 39 from Scopus, 67 from Medline, and 16 from Embase.