Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem.

Antibodies targeting epitopes through germline-encoded motifs can be found in different individuals. While these public antibodies are often beneficial, they also pose hurdles for subdominant antibodies to emerge. Here, we use transgenic mice that reproduce the human IGHV1-6901 germline-encoded antibody response to the conserved stem epitope on group 1 hemagglutinin (HA) of influenza A virus to show that this germline-endowed response can be overridden by a subdominant yet cross-group reactive public antibody response.

Integrating systems of power and privilege in the study of resilience.

Although current approaches to the study of resilience acknowledge the role of context, rarely do those conceptualizations attend to societal systems and structures that include hierarchies of power and privilege-namely systems of racism, colonialism, patriarchy, and capitalism-nor do they articulate how these structural realities are embedded within individual experiences. We offer critiques of the current literature from this structural lens, using the concept of master narratives to articulate the incomplete and, at times, damaging story that the discipline of psychology has told about resilience. We then provide three models that center history, systems, and structures of society that can be employed in the study of resilience.

Using Intersectionality to Understand How Structural Domains Are Embedded in Life Narratives.

Objective: This study draws on life narrative data and an intersectional framework to explore features of narratives around structural domains, aiming to better understand the possible impacts of these domains on identity.

Method: Through in-depth semi-structured interviews with 177 young adults from primarily minoritized groups (73% Asian American or Latine, 59% Women, Median Parent Income = $50,001 to $75,000), we gathered 885 life narratives. Young adults narrated a domain-general, ethnic/racial, gender, social class, and intersectional experience.

Using structural topic modeling to understand ethnicity-related narratives.

Objective: Narrative identity is a promising approach for understanding the content of individuals' ethnic identities but can be limited by the time-intensive nature of human coding and the reliance on preestablished coding systems.

Background: The aim of our preregistered study is to elucidate the content of individuals' ethnicity-related experiences using a novel statistical approach.

Method: We applied structural topic modeling (STM), a natural language processing tool, to narratives written by an ethnically diverse sample of 1149 young adults about a moment they felt aware of their ethnicity.

Research as resistance: Naming and dismantling the master narrative of "good" science.

The call for psychological science to make amends for "causing harm to communities of color and contributing to systemic inequities" (American Psychological Association, 2022a) requires a critical acknowledgment that science is not neutral but a sociopolitical and ideological endeavor. From its inception, psychology used science to produce what was framed as incontrovertible "hard" evidence of racial hierarchy, infallible "proof" that white people (i.e.

Evaluating a School-Based Intervention on Adolescents' Ethnic-racial Identity in Sweden.

Finding developmentally appropriate ways to support youth in understanding their own ethnic-racial identity is needed, particularly in contexts like Sweden where such support is not the norm. This preregistered longitudinal study examined whether an 8-week school-based intervention, the Identity Project, impacted youth ethnic-racial identity exploration (participation and search), resolution, private regard, and centrality. Participants were 509 adolescents in the 10 grade (M = 16.

Identification of a Cryptic Pocket in Methionine Aminopeptidase-II Using Adaptive Bandit Molecular Dynamics Simulations and Markov State Models.

Methionine aminopeptidase-II (MetAP-II) is a metalloprotease, primarily responsible for the cotranslational removal of the N-terminal initiator methionine from the nascent polypeptide chain during protein synthesis. MetAP-II has been implicated in angiogenesis and endothelial cell proliferation and is therefore considered a validated target for cancer therapeutics. However, there is no effective drug available against MetAP-II.

Ethnic-Racial Identity and Attitude Change: Assessments of Outgroup and Diversity Attitudes among Adolescents in Sweden.

Outgroup and diversity attitudes are important components of intercultural understanding and well-being. Despite the potential of ethnic-racial identity development as a means to foster positive outgroup and diversity attitudes, little is known about its effectiveness in rapidly diversifying contexts such as Sweden. This pre-registered study filled this gap by examining if adolescents taking part in an intervention focused on ethnic-racial identity exploration, the Identity Project, also reported change in outgroup and diversity attitudes, and whether migration background, education type, and ethnic-racial identity development predicted such change.

Evaluation of the Impact of Irradiance Lamps and Storage Media on Elution of TEGDMA from Dental Composites.

Objectives:  The aim of this study was to evaluate and compare the effect of irradiance light and storage media on the elution of triethylene glycol dimethacrylate (TEGDMA) from conventional Filtek Z350XT 3M ESPE and two bulk-fill composites Shofu Beautifil-Bulk and Filtek Bulk fill flowable 3M ESPE using high-performance liquid chromatography (HPLC).

Materials And Methods:  Shofu Beautifil-Bulk, Filtek Bulk fill flowable 3M ESPE, and Filtek Z350XT 3M ESPE were the three types of composites used in this study. Disk shaped samples of 4-mm thickness and 10-mm diameter were fabricated using a stainless steel mold and were polymerized using light emitting diode (LED) and quartz tungsten halogen (QTH) lamps.

A guide for social science journal editors on easing into open science.

Journal editors have a large amount of power to advance open science in their respective fields by incentivising and mandating open policies and practices at their journals. The Data PASS Journal Editors Discussion Interface (JEDI, an online community for social science journal editors: www.dpjedi.

Assessment of Salivary MMP-8 and IL-1β for the Diagnosis of Periodontal Diseases in Pakistani Population.

Objective:  Clinical methods use the subjective diagnosis of periodontal diseases by visual observation that could result in differences and variability of diagnosis. The addition of specific markers could aid in the accurate diagnosis of the local population. The objective of the study was to target two of the major proteins for possible significance in such an approach.

Attempting Well-Tempered Funnel Metadynamics Simulations for the Evaluation of the Binding Kinetics of Methionine Aminopeptidase-II Inhibitors.

Understanding the unbinding kinetics of protein-ligand complexes is considered a significant approach for the design of ligands with desired specificity and safety. In recent years, enhanced sampling methods have emerged as effective tools for studying the unbinding kinetics of protein-ligand complexes at the atomistic level. MetAP-II is a target for the treatment of cancer for which not a single effective drug is available yet.

Testing exploratory narrative processing as a mechanism of change in identity status processes over 4 years in college-going emerging adults.

We examined the critical task of emerging adulthood-identity development-via analyses of trajectories of identity exploration and commitment over the college years, as well as whether narrative processing of important events during this period served as a mechanism of identity exploration and commitment. We took advantage of a unique and comprehensive longitudinal design, which included 12 waves of data, both quantitative and qualitative assessments, collected over 4 years, on two distinct college campuses in the Northwestern and Northeastern regions of the United States (Wave 1, = 639; growth models using all waves, = 251). Analyses for this study were preregistered after data collection was complete.

Refined semi-lethal aerosol H5N1 influenza model in cynomolgus macaques for evaluation of medical countermeasures.

Highly pathogenic avian influenza A H5N1 viruses cause high mortality in humans and have pandemic potential. Effective vaccines and treatments against this threat are urgently needed. Here, we have refined our previously established model of lethal H5N1 infection in cynomolgus macaques.

"… Inside of my home, I was getting a full dose of culture": Exploring the ecology of Indigenous peoples' development through stories.

According to the Indigenist ecological systems model (Fish et al., 2022; Fish & Syed, 2018), Indigenous Peoples' histories and cultures are critical to their development. However, the inclusion of Indigenous Peoples' histories and cultures in their environments is complicated by settler colonialism-a societal structure that seeks to eliminate such important contexts.

Building causal knowledge in behavior genetics without racial/ethnic diversity will result in weak causal knowledge.

Behavior genetics often emphasizes methods over the underlying quality of the psychological information to which the methods are applied. A core aspect of this quality is the demographic diversity of the samples. Building causal genetic models based only on European-ancestry samples compromises their generalizability.

Bioaccumulation of Chloropyrifos Organo-pesticide and Its Toxicogenic Association with Antioxidant GSTP1 in Pakistani Pest Control Workers.

Synthetic pesticides are employed to enhance agricultural production. Chronic exposure to organophosphate (OP) pesticides may be a source of health problems. The present study was designed to examine an association of GSTP1 (rs1695) polymorphism with OP pesticide chronic exposure.

A primer for choosing, designing and evaluating registered reports for qualitative methods.

Registered reports are a publication format that involves peer reviewing studies both before and after carrying out research procedures. Although registered reports were originally developed to combat challenges in quantitative and confirmatory study designs, today registered reports are also available for qualitative and exploratory work. This article provides a brief primer that aims to help researchers in choosing, designing, and evaluating registered reports, which are driven by qualitative methods.

Registered Reports in Child Development: Introduction to the Special Section.

Registered Reports (RRs) are an emerging format for publishing empirical journal articles in which the decision to publish an article is based on sound conceptualization, methods, and planned analyses rather than the specific nature of the results. This article introduces the Special Section on Registered Reports in Child Development by describing what RRs are and why they are necessary, outlining the thought process that guided the Special Section, describing key thematic insights across the eight articles included in the collection, and providing recommendations for developmental researchers interested in publishing via the RR format. This article also serves as a formal announcement that RRs will be a standard publishing option at Child Development, effective immediately.

Utilization of wild Cressa cretica biomass for pectinase production from a halo-thermotolerant bacterium.

Halophytes are the native inhabitants of saline environment. Their biomass can be considered as a potential substrate for the production of microbial enzymes. This study was intended at feasible utilization of a halophytic biomass, Cressia cretica, for pectinase production using a halo- and thermo-tolerant bacterium, Bacillus vallismortis MH 10.

Colloidal gold based immunochromatographic detection of Mycoplasmopsis synoviae infection and its prevalence in avian species of Karachi, Pakistan.

Avian mycoplasmosis is an infection that commonly prevails in birds, particularly in poultry chickens. Among mycoplasmosis causing organisms, Mycoplasmopsis synoviae is a predominant and lethal pathogen to the aves. Considering the increased incidence of infections by M.

Deciphering Structural and Dynamical Properties of Hydrated Cobalt Porphyrins via Ab Initio Quantum Mechanical Charge Field Molecular Dynamics Simulation.

The present study successfully implemented the ab initio quantum mechanical charge field molecular dynamics (QMCF MD) formalism for the investigation of structural and dynamical properties of hydrated cobalt-porphyrin complexes. Considering the significance of cobalt ions in biological systems (for instance, vitamin B12), which reportedly incorporate cobalt ions in a d6, low spin, +3 state chelated in the corrin ring, an analog of porphyrin, the current study is focused on cobalt in the oxidation states +2 and +3 bound to the parent porphyrin lead structures embedded in an aqueous solution. These cobalt-porphyrin complexes were investigated in terms of their structural and dynamical properties at the quantum chemical level.

Isolation of lectin from Musa acuminata for its antibiofilm potential against Methicillin-resistant Staphylococcus aureus and its synergistic effect with Enterococcus species.

Methicillin resistant Staphylococcus aureus (MRSA) is an emerging pathogen posing a considerable burden on the healthcare system due to its involvement in skin and soft tissue infections (SSTIs). Lectins are carbohydrate binding proteins found ubiquitously in animals, plants and microorganisms. Extraction and isolation of proteins from Musa acuminata were performed by using Affinity chromatography with Sephadex G 75 to determine antibiofilm activity against MRSA.

Cognitive scripts and narrative identity are shaped by structures of power.

Constructing a narrative identity involves developing an understanding of oneself as integrated through time and across contexts, a task critical to psychosocial development and functioning. However, research has primarily focused on the individual in isolation or in highly localized contexts. This is problematic because narrative identity is profoundly shaped by structures of power; thus, we cannot understand how individuals understand themselves through time, across contexts, and as a member of a particular community without attention to the structure of society.

Progress in vaccine development for infectious diseases-a Keystone Symposia report.

The COVID-19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity possible. While several different vaccines have been successful at stemming the morbidity and mortality associated with various infectious diseases, many pathogens/diseases remain recalcitrant to the development of effective vaccination. Recent advances in vaccine technology, immunology, structural biology, and other fields may yet yield insight that will address these diseases; they may also help improve societies' preparedness for future pandemics.