Publications by authors named "Syed Mastan Ali"
The most frequent type of age-related dementia is Alzheimer's disease. To discover novel therapeutic agents for Alzheimer's disease, a series of substituted pyrimidine derivatives were synthesized and evaluated for anti-Alzheimer's activity. All the synthesized compounds were validated by HNMR, CNMR, and HRMS to assess the structural conformance of the newly synthesized compounds.
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- - The study explores an innovative reaction process involving the Oxa-Michael addition of penta-substituted phenols to a tethered enone, utilizing iodine as an oxidizing agent, resulting in the successful synthesis of ten C-dimethylated flavones with yields ranging from 60-89%.
- - Subsequently, the efficacy of these compounds against Mycobacterium tuberculosis was assessed using the Microplate Alamar Blue test, revealing two compounds (10e, 10h) with significant antibacterial sensitivity.
- - Anticancer properties were evaluated in human lung cancer cell lines (A549) using the MTT assay, where four flavones exhibited notable activity with IC values between 39 and 48 μM,