Investigating In Situ Expression of Neurotrophic Factors and Partner Proteins in Irreversible Pulpitis.

Introduction: In situ assessments of neurotrophic factors and their associated molecular partners have not been explored to date, particularly in humans. The present investigation aimed to explore the expressional dysregulation of neurotrophic factors (nerve growth factor [NGF], brain derived neurotrophic factor [BDNF], and NT4/5), their receptors (TrkA and TrkB), and their modulators (USP36 and Nedd4-2) directly in irreversibly inflamed human pulp tissues.

Methods: Forty samples each of healthy and irreversibly inflamed pulp were extirpated for the study.