Three Pt-Pt Complexes with Donor-acceptor Feature: Anticancer Activity, DNA Binding Studies and Molecular Docking Simulation.

Background: Due to their unique properties and potential applications in variety of areas, recently, a special attention is given to the binuclear platinum (II) complexes. They reveal a highly tunable features upon the modification of their cyclometallating and bridging ligands.

Objective: The aim of this study was to evaluate the anticancer activity and DNA binding affinity of three binuclear platinum (II) complexes, including ht-[(p-FCH)Pt(µ-PN)(µ-NP)PtMe](CFCO)(1), ht-[(p- MeCH)Pt(µ-PN)(μ-NP)Pt(p MeCH) Me] (CFCO)(2) and ht-[PtMe(µ-PN)2](CFCO) (3).