Revisiting hereditary tyrosinemia Type 1-spectrum of radiological findings.

Tyrosinemia is a rare metabolic disease showing autosomal recessive inheritance associated with a deficiency of the enzyme fumarylacetoacetate hydrolase. Absence of this enzyme results in the accumulation of succinylacetone in the tissues which predominantly results in liver injury, renal tubular damage, and neurological manifestation resembling porphyrias. The complications that can develop without appropriate treatment include renal tubular dysfunction, growth failure, rickets, neurological crises, hepatomegaly, and possible hepatocellular carcinoma.

Solitary Fibrous Tumor of Kidney.

Solitary fibrous tumor of kidney is an unusual condition. It is spindle cell tumor with mesenchymal in origin so most commonly reported cases are in pleura, and extra-pleural sites are very rare. It is mostly benign in nature but malignant variant are also reported.

Lumbosacral dysraphism as cause of neurogenic bladder: Magnetic Resonance Imaging based study from SIUT Pakistan.

Objective: To find the frequency and types of spinal dysraphism in patients presenting with neurogenic bladder dysfunction.

Methods: The cross-sectional study was conducted at the Sindh Institute of Urology and Transplantation, Karachi, from February to September 2011, and comprised patients of either gender 5-15 years of age with neurogenic bladder suspected to be due to lumbosacral dysraphism. They all had magnetic resonance imaging of lumbosacral spine.

Non-alcoholic fatty liver disease among visitors to a hepatitis awareness programme.

Background And Aims: Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide. The present study aimed to evaluate the prevalence of NAFLD among the visitors screened on World Hepatitis Day 2010 and 2011.

Methods: Attendees of the hepatitis awareness programme (n = 928) were offered screening to rule out liver ailments.

Frequency of complications in image guided percutaneous nephrostomy.

Objective: To assess the frequency of complications in image-guided percutaneous nephrostomy and to identify common sources of error.

Methods: The study was carried out at the Sindh Institute of Urology and Transplantation, Karachi, between November 2006 and May 2007. Patients of all age groups between 1 and 80 years were included using nonprobability convenience sampling technique.

Adverse events following transarterial chemoembolization for hepatocellular carcinoma and factors predicting such events.

Objective: To document the adverse events after transarterial chemoembolisation and factors predicting such events.

Methods: The prospective observational study was conducted at the Sindh Institute of Urology and Transplantation, Karachi, from November 2009 to November 2011. All patients diagnosed as hepatocellular carcinoma were included in this study.

Thalamic and midbrain infarct during transarterial chemoembolization of hepatocellular carcinoma.

Transarterial chemoembolization (TACE) is a well accepted and a relatively safe procedure, however certain rare and serious complications may occur during or after the procedure with profound morbidity and mortality. Only a few cases have been reported describing cerebral embolization during the procedure. We are reporting a case in which cerebral lipiodal embolization occurred in the second session of TACE, during the procedure and without any evidence of pulmonary embolism causing midbrain and thalamic infarct.

Evaluation of children with urolithiasis.

Objectives: To describe an evaluation protocol for pediatric stone formers for risk assessment and management strategies.

Materials And Methods: Between 2002-2006, 2618 children of age three months to 15 years were evaluated for stone disease. Evaluation included demographics, history, anthropometry, diet, ultrasound, X-ray KUB, IVU, blood and 24h urine chemistry and cultures.