Simulation-based training improves physicians' performance in patient care in high-stakes clinical setting of cardiac surgery.

Background: Simulation-based training is useful in improving physicians' skills. However, no randomized controlled trials have been able to demonstrate the effects of simulation teaching in real-life patient care. This study aimed to determine whether simulation-based training or an interactive seminar resulted in better patient care during weaning from cardiopulmonary bypass (CPB)-a high stakes clinical setting.

Familial blepharophimosis-like syndrome with esotropia, uveal coloboma, and short stature.

Background: Interstitial deletion of Hsa 3q involves FOXL2, the gene responsible for blepharophimosis-ptosis-telecanthus-epicanthus inversus (BPES). Thought to be due to a contiguous gene syndrome, the recognizable phenotype of 3q interstitial deletion includes BPES facies and has not been associated with other loci.

Objective: To describe a familial syndrome that resembles the interstitial deletion of 3q clinically, but does not map to the FOXL2 region.