Voriconazole-Induced Hepatotoxicity Presenting With Severe Hepatic Encephalopathy After Liver Transplantation.

Voriconazole-induced hepatotoxicity is a relatively rare but serious clinicopathologic entity. This drug is frequently used for invasive aspergillosis and other fungal infections. We report a patient with alcoholic cirrhosis who developed hepatic encephalopathy due to voriconazole administered for invasive pulmonary aspergillosis and subsequently showed marked improvement in mental status with dose adjustment of the drug.

Small Bowel Perforation Secondary to Esophageal Stent Migration: A Comparative Review of Six Cases.

Esophageal stent placement is used to treat benign strictures, esophageal perforations, fistulas and for palliative therapy of esophageal cancer. Although it is a safe and effective method, complications are increasing the morbidity and mortality rate. Small bowel perforation as a result of esophageal stent migration is a remarkably rare occurrence.

Salvage Plasmapheresis for Post-hepatectomy Liver Failure.

In the latest decades, an important change has been registered in liver surgery related to the progress of surgical techniques, critical care, and postoperative treatment, allowing a sharp decrease in mortality and morbidity. However, management of post-hepatectomy liver failure (PHLF) still remains a challenge and no supportive treatment has been found to be generally effective. The present study is a reappraisal of plasmapheresis as a potential supportive measure in patients with PHLF following major liver resection.

Cytomegalovirus Colitis in Immunocompetent Patients.

Cytomegalovirus colitis is common in immunocompromised patients, but rare in immunocompetent patients. The present study not only represents the colonoscopy and pathological findings, but also applies the method of diagnosing and treating cytomegalovirus colitis in immunocompetent patients.

Rectal cancer patients benefit from implementation of a dedicated colorectal cancer center in a Veterans Affairs Medical Center.

Background: A dedicated colorectal cancer (CRC) center was created in a Veterans Affairs Medical Center with the intent of improving quality of patient care and multidisciplinary cooperation.

Methods: Retrospective and prospective databases before and after creation of the CRC center, respectively, were created. Patients entered in each database included those requiring surgical intervention for CRC treatment.