Fluconazole-resistant Candida parapsilosis complex candidemia and analysis of mutations in the ERG11 gene from Pakistan.

Background: Recent reports of the emergence of fluconazole resistance in Candida parapsilosis species complex poses a challenge, more specifically in settings where echinocandin-based treatment regime is not feasible.

Objective: This study reported emergence of fluconazole resistance in C. parapsilosis species complex strains isolated from blood cultures.

Antifungal susceptibility profile of invasive isolates (2009-2020) from a tertiary care hospital laboratory in Pakistan.

Invasive infections with are a global concern due to poor clinical outcomes and propensity to acquire resistance to antifungal agents Monitoring emerging resistance and trends in , an important agent of candidemia in Pakistan, is critical for patient management; data that is missing from Pakistan Thus, this study evaluated antifungal resistance and MICs) distribution in invasive isolates from Pakistan This cross-sectional and retrospective study was conducted from January 2009 to March 2020 at a clinical laboratory in Pakistan that has a nation-wide network. Antifungal susceptibility data of 277 candidemia, deep organ and soft tissue (invasive) isolates against fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, micafungin, caspofungin and amphotericin B was retrieved. Susceptibility testing was performed using colorimetric broth microdilution and interpreted using CLSI criteria.