Publications by authors named "Syed Asif Haque"
Background: Further understanding of adverse clinical event rates in patients with chronic kidney disease (CKD) is required for improved quality of care. This study described baseline characteristics, adverse clinical event rates, and mortality risk in patients with CKD, accounting for CKD stage and dialysis status.
Methods: This retrospective, noninterventional cohort study included data from adults (aged ≥ 18 years) with two consecutive estimated glomerular filtration rates of < 60 ml/min/1.
Introduction: Further understanding of adverse clinical events in patients with chronic kidney disease (CKD) is needed. This study aimed to describe characteristics of patients with nondialysis-dependent (NDD) and dialysis-dependent (DD) CKD and to assess incidence rates of uncommon adverse clinical events of interest in these patients.
Methods: This retrospective study used electronic medical record data from USA CKD patients (≥18 years) with estimated glomerular filtration rate (eGFR) <60 mL/min/1.
Article Synopsis
- - Immune checkpoint inhibitors (ICIs) are effective cancer treatments but can cause unique liver injuries known as immune-mediated liver injury caused by checkpoint inhibitors (ILICI), which differ from typical drug-induced liver injuries.
- - There is a lack of standardized best practices for managing ILICI during drug development, even though awareness and guidelines for these immune-related adverse effects are increasing.
- - This publication provides recommendations for monitoring, diagnosing, and managing ILICI in clinical trials, focusing on best practices related to liver test monitoring, detection, causality assessment, and treatment protocols.