Identification of L. Methanolic-Leaf-Extract-Derived Metabolites Exhibiting Xanthine Oxidase Inhibitory Activities: In Vitro and In Silico Approaches.

There is a growing interest in the discovery of novel xanthine oxidase inhibitors for gout prevention and treatment with fewer side effects. This study aimed to identify the xanthine oxidase (XO) inhibitory potential and drug-likeness of the metabolites present in the methanolic leaf extract of L. using in vitro and in silico models.

Anticancer Activity of Leaves Extract on Sprague-Dawley Rats: Model.

Medicinal plants are now used to treat cancer due to the presence of bioactive compounds. Apart from the plants, mangroves also possess rich bioactive compounds with high medicinal activity. Based on the ethnobotanical attributes of , we are keen to work with its anticancer activity.

Lam. (Mangrove) Bark Extract Reduces Ethanol-Induced Liver Cell Death and Oxidative Stress in Swiss Albino Mice: In Vivo and In Silico Studies.

The bark extract of (BERM) was recently reported for its prominent in vitro protective effects against liver cell line toxicity caused by various toxicants, including ethanol. Here, we aimed to verify the in vivo hepatoprotective effects of BERM against ethanol intoxication with the prediction of potential targets employing in silico studies. An oral administration of different concentrations (100, 200 and 400 mg/kg body weight) of BERM before high-dose ethanol via intraperitoneal injection was performed in mice.

HPLC characterization, acute and sub-acute toxicity evaluation of bark extract of in Swiss Albino mice.

Aim: , commonly called as 'red mangrove' grows in the tropical and sub-tropical regions and on the sheltered shores. The bioactive compounds from the plant have been used in the treatment of wide range of diseases. Though the beneficial effects have been reported, the safety and toxicological studies are not carried out.

Propugnating Effect of Bark of Against Different Toxicants Viz Carbon Tetrachloride, Ethanol and Paracetamol on HepG Cell Lines.

Objective: The aim of the study was to evaluate the hepatoprotective activity of the bark extract (Ethanol: Water) in the ratio of (3:1) of (BERM) by intoxicating the HepG cell lines with different toxicants viz, CCL, Ethanol and Paracetamol with different concentrations of the extract were used. The HepG cell lines were subjected to MTT Assay for studying the cytotoxicity.

Methods: HepG cells were plated using 96 well plate in 10% bovine serum, exposed to different toxicants viz, 2% CCl, 60% Ethanol and 14 mM Paracetamol respectively.