Use of anticoagulants to improve pregnancy outcomes in couples positive for M2 haplotype: A systematic review.

Background: Placental mediated pregnancy complications (PMPC) are common, often recurring, and pose a significant health risk to mother and fetus. Evidence suggests that the hypercoagulable state associated with many PMPC, could reflect reduced expression of Annexin 5 (ANXA5), a naturally occurring anticoagulant protein in placental tissue. The ANXA5 M2 haplotype is a genetic variant, which results in reduced expression of ANXA5 protein.

Realist evaluation of the implementation and impact of the NHS carbon reduction strategy in the UK.

Objectives: To evaluate the extent to which organisational factors facilitate or inhibit the implementation of the National Health Service (NHS) carbon reduction strategy within acute hospital settings.

Setting: A single acute NHS Trust with four satellite sites which serve more than 2 million patients annually in Central England.

Participants: Interviews with a purposive sample of 10 stakeholders, including those who conceptualised the intervention and those who were responsible for its implementation.