Acute cutaneous wounds treated with human decellularised dermis show enhanced angiogenesis during healing.

Background: The influence of skin substitutes upon angiogenesis during wound healing is unclear.

Objectives: To compare the angiogenic response in acute cutaneous human wounds treated with autogenic, allogenic and xenogenic skin substitutes to those left to heal by secondary intention.

Methods: On day 0, four 5mm full-thickness punch biopsies were harvested from fifty healthy volunteers (sites 1-4).