Publications by authors named "Syed A Agha"
Background: The impact of digoxin on outcomes of patients with advanced heart failure (HF) receiving optimal contemporary therapy is not known.
Methods And Results: We retrospectively reviewed data of 455 advanced HF patients referred for transplant evaluation (age, 52+/-12 years; ejection fraction, 18.3+/-8%); 227 (49.
Background: Incremental value of echocardiography over clinical parameters for outcome prediction in advanced heart failure (HF) is not well established.
Methods And Results: We evaluated 223 patients with advanced HF receiving optimal therapy (91.9% angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, 92.
Background: Little is known about the epidemiology of stroke in chronic systolic and diastolic heart failure (HF) patients in normal sinus rhythm (NSR) receiving angiotensin-converting enzyme (ACE) inhibitors. Because all HF patients in the Digitalis Investigation Group (DIG) trial (N=7788) were in NSR and nearly all were receiving ACE inhibitors, a survey-based stroke-sub-study was conducted but its findings have never been published.
Methods: DIG investigators confirmed a total 222 cases of stroke of which 144 had neurological deficit ≥24 h.
Background: Impaired renal function portends poor heart failure (HF) outcomes. The Seattle Heart Failure Score (SHFS), a multimarker risk assessment tool, however does not incorporate renal function. In this study, we assessed the incremental value of renal function over the SHFS in patients with advanced HF on contemporary optimal treatment.
View Article and Find Full Text PDFObjectives: The aim of this study was to validate the Seattle Heart Failure Model (SHFM) in patients with advanced heart failure (HF).
Background: The SHFM was developed primarily from clinical trial databases and extrapolated the benefit of interventions from published data.
Methods: We evaluated the discrimination and calibration of SHFM in 445 advanced HF patients (age 52 +/- 12 years, 68.
Introduction: Ischemic heart disease (IHD) is common in heart failure (HF), yet the association between incident coronary revascularization and mortality in these patients has not been examined in a propensity-matched study.
Methods: In the Digitalis Investigation Group trial, 2853 patients without coronary revascularization and 120 patients with coronary revascularization during the first three years were alive at the end of three years. We used propensity scores to match 119 and 357 patients with and without coronary revascularization.
Background: Racial differences in the epidemiology and outcomes of heart failure are well known. However, the association of race with the natural history of heart failure has not been previously studied in a propensity-matched population of chronic heart failure in which all measured baseline patient characteristics are well-balanced between the races.
Methods And Results: Of the 7788 patients with chronic systolic and diastolic heart failure in the Digitalis Investigation Group trial, 1128 were nonwhites.
Objectives: To compare the effects of topical collagen and hydrocolloid on pressure ulcer healing.
Design: Randomized (allocation concealed), single-blind (outcome assessors), controlled trial with 8-week follow-up.
Setting: Eleven nursing homes in central Illinois.