Playing the Admission Game: Young People and Their Parents Negotiating Access or Discharge to Adolescent Inpatient Mental Health Services.

Background: Only children and young people with the highest need for mental health care or support are admitted to an inpatient setting. There has been a recent shift in emphasis with the aim of inpatient care being short and focussed, care is transferred back to the community on discharge. Little is known about what young people and their parents understand about admission and discharge criteria to these inpatient facilities.

Could the Inflation Reduction Act Maximum Fair Price Hurt Patients?

The Inflation Reduction Act's Medicare Drug Price Negotiation Program allows the federal government to negotiate caps for select medications. These price caps may reduce revenue for the pharmacy benefit managers (PBMs) that negotiate the actual price paid for medicines in the U.S.

Salmonella exploits membrane reservoirs for invasion of host cells.

Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into host cells during infection. The effectors modulate host cell machinery to drive uptake of the bacteria into vacuoles, where they can establish an intracellular replicative niche. A remarkable feature of Salmonella invasion is the formation of actin-rich protuberances (ruffles) on the host cell surface that contribute to bacterial uptake.

Modeling the Effects of Formulary Exclusions: How Many Patients Could Be Affected by a Specific Exclusion?

Medication formularies, initially designed to promote the use of cost-effective generic drugs, are now designed to maximize financial benefits for the pharmacy benefit management companies that negotiate purchase prices. In the second-largest pharmacy benefit management formulary that is publicly available, 55% of mandated substitutions are not for generic or biosimilar versions of the same active ingredient and/or formulation and may not be medically or financially beneficial to patients. We modeled the effect of excluding novel agents for atrial fibrillation/venous thromboembolism, migraine prevention, and psoriasis, which all would require substitution with a different active ingredient.

A fast parallelized DBSCAN algorithm based on OpenMp for detection of criminals on streaming services.

Introduction: Streaming services are highly popular today. Millions of people watch live streams or videos and listen to music.

Methods: One of the most popular streaming platforms is Twitch, and data from this type of service can be a good example for applying the parallel DBSCAN algorithm proposed in this paper.

Registered Nurses' and nursing students' perspectives on moral distress and its effects: A mixed-methods systematic review and thematic synthesis.

Aim: To examine Registered Nurses (RNs') and nursing students' perspectives on factors contributing to moral distress and the effects on their health, well-being and professional and career intentions.

Design: Joanna Briggs Institute mixed-methods systematic review and thematic synthesis. Registered in Prospero (Redacted).

Nurses' coping strategies caring for patients during severe viral pandemics: A mixed-methods systematic review.

Background: Nurses play an essential role in responding to severe viral disease which bring considerable challenges to their personal and professional well-being. This subsequently can affect the delivery of care and healthcare systems' organisational capacity to respond. Understanding nurses' experiences of these challenges will help inform healthcare policies.

Global Proximity Interactome of the Human Macroautophagy Pathway.

BioID: proximity-dependent biotin identification; GO: gene ontology; OSBPL: oxysterol binding protein like; VAPA: VAMP associated protein A; VAPB: VAMP associated protein B and C.

An interpretative phenomenological analysis of young men's experiences of addressing their sexual health and the importance of researcher reflexivity.

Background: Incidence of sexually transmitted infections has increased in both young men and young women. Young men do not access sexual health services in the same numbers as young women, this study sought to discover young men's experiences.

Aims: This paper reports one overarching theme from an interpretative phenomenological study that sought to discover the experiences of young males (aged 20-24) addressing or failing to address their sexual health.

Microbiology and Drug Resistance of Pathogens in Patients Hospitalized at the Nephrology Department in the South of Poland.

A retrospective study was conducted among 498 patients with urinary tract infections (UTI) referred to our department from January 2013 to December 2015. This study was performed to evaluate the etiology of UTI and the antibiotic susceptibility profile of Escherichia coli ( E. coli ) as the main etiological factor in different age groups.

PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN.

Centrosome structure, function, and number are finely regulated at the cellular level to ensure normal mammalian development. Here, we characterize PPP1R35 as a novel bona fide centrosomal protein and demonstrate that it is critical for centriole elongation. Using quantitative super-resolution microscopy mapping and live-cell imaging we show that PPP1R35 is a resident centrosomal protein located in the proximal lumen above the cartwheel, a region of the centriole that has eluded detailed characterization.

Analytical strategies to detect enobosarm administration in bovines.

Selective androgen receptor modulators (SARMs) are a novel class of androgen receptor ligands. They are intended to exhibit the same kind of effects as androgenic drugs, like anabolic steroids, but be much more selective in their action, targeting particular tissues without any undesirable effects on others. While the main applications of these synthetic substances are for therapeutic purposes, they also have a high potential for misuse in veterinary practice and the sporting world.

Selective androgen receptor modulators: comparative excretion study of bicalutamide in bovine urine and faeces.

Besides their development for therapeutic purposes, non-steroidal selective androgen receptor modulators (non-steroidal SARMs) are also known to impact growth-associated pathways as ligands of androgenic receptors (AR). They present a potential for abuse in sports and food-producing animals as an interesting alternative to anabolic androgenic steroids (AAS). These compounds are easily available and could therefore be (mis)used in livestock production as growth promoters.

[Roux-en-Y gastric bypass in a candidate for kidney transplant].

Obesity is a factor limiting access to kidney transplantation because of the high risk of perioperative complications, worse graft function and patients' survival. We present a case of an obese patient (BMI-38 kg/m2) with hypertension, diabetes and end-stage kidney disease caused by chronic glomerulonephritis treated with hemodialysis, who was excluded from transplantation because of obesity. The patient underwent Roux-en-Y gastric by-pass surgery as a preparation for kidney transplantation.

[Evaluation of the renal excretory function using estimated GFR in patients coming to Voivoidship St. Lukas Hospital in Tarnow in the years 2007-2010].

Background: Studies concerning chronic kidney disease frequency are becoming of more and more interest. This is connected with an increased morbidity and diagnosis of chronic kidney disease. The aim of this study was an analysis of glomerular filtration rate results in patients coming to Emergency Department (ED) of Voivodship St.

[Community-acquired urinary tract infections in the internal and nephrology ward: etiology and selected risk factors].

Background: Community-acquired urinary tract infections (UTI) are one of the most common types of infections. In some cases they become a cause of hospitalization and various, sometimes serious complications.

Objectives: The aim of this study was to analyze community-acquired UTI in patients hospitalized in the internal nephrology ward, taking into account causative pathogens, gender, age as well as selected risk factors.

[Urinary tract infections in adults].

Review of urinary tract infections in adults including etiology, pathogenesis, classification and the most important therapeutic recommendations. Urinary tract infections are still a common clinical problem occurring more often in sexually active women, pregnancy, elderly , after catherization of a urinary bladder and urological surgery as well as in the co-existence of diabetes or nephrolithiasis. Due to the anatomical differences, women suffer more often than men.

Super-Resolution Microscopy: From Single Molecules to Supramolecular Assemblies.

Super-resolution microscopy (SRM) methods have allowed scientists to exceed the diffraction limit of light, enabling the discovery and investigation of cellular structures at the nanometer scale, from individual proteins to entire organelles. In this review we survey the application of SRM in elucidating the structure of macromolecules in the native cellular environment. We emphasize how SRM can generate molecular maps of protein complexes and extract quantitative information on the number, size, distribution, and spatial organization of macromolecules.

[Vascular access in diabetic patients. Are these patients "difficult"?].

Diabetics with stage V chronic kidney disease (CKD) on hemodialysis (HD) are considered as "difficult patients", because of problems with creation of the vascular access. There is controversy regarding the results and recommendations for preparation of the vascular access in these patients. The aim of this retrospective study was to evaluate the results of creating different types of arteriovenous fistula (AVFs) in consecutive series of patients starting dialysis treatment.

[Outcome of patients with acute kidney injury in the course of neoplastic diseases].

Patients with malignancies are a group of increased risk of acute kidney injury (AKI). The aim of this study was to evaluate selected parameters characterizing acute kidney injury in patients with malignancies such as the cause ofAKI, previous kidney function, diuresis, duration of oligoanuria, the number of dialysis sessions, mortality and normalization of renal function in the course of AKI. We analyzed data of 387 patients with AKI (155 women, 232 men) aged 26-96 years treated in hospital wards of nephrological profile in the most requiring dialysis.

Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases.

GTPases are critical molecular switches involved in a wide range of biological functions. Recent phylogenetic and genomic analyses of the large, mostly uncharacterized COG0523 subfamily of GTPases revealed a link between some COG0523 proteins and metal homeostasis pathways. In this report, we detail the bioinorganic characterization of YjiA, a representative member of COG0523 subgroup 9 and the only COG0523 protein to date with high-resolution structural information.

Relationship between Ni(II) and Zn(II) coordination and nucleotide binding by the Helicobacter pylori [NiFe]-hydrogenase and urease maturation factor HypB.

The pathogen Helicobacter pylori requires two nickel-containing enzymes, urease and [NiFe]-hydrogenase, for efficient colonization of the human gastric mucosa. These enzymes possess complex metallocenters that are assembled by teams of proteins in multistep pathways. One essential accessory protein is the GTPase HypB, which is required for Ni(II) delivery to [NiFe]-hydrogenase and participates in urease maturation.