Use of multi-modelling methods to inform conservation and reintroductions of pine marten in Britain.

The successful onset of recovery of the European pine marten () in some parts of Britain through range expansion and, more recently translocation for reintroductions, has resulted in a strong interest in reintroduction projects throughout the country. However, the geographic scope and conservation goals of these initiatives are often local and lack consideration of how they fit within the wider context of national-scale pine marten conservation. Here, we aim to maximize conservation benefit strategically at a national level by developing a simple, transparent, and transferable framework based on landscape modelling methods and spatially explicit population viability analyses.

Adding pattern and process to eco-evo theory and applications.

Eco-evolutionary dynamics result when interacting biological forces simultaneously produce demographic and genetic population responses. Eco-evolutionary simulators traditionally manage complexity by minimizing the influence of spatial pattern on process. However, such simplifications can limit their utility in real-world applications.

HexFire: A Flexible and Accessible Wildfire Simulator.

As fire frequency and severity grow throughout the world, scientists working across a range of disciplines will increasingly need to incorporate wildfire models into their research. However, fire simulators tend to be highly complex, time-consuming to learn, and difficult to parameterize. As a result, embracing these models can prove impractical for scientists and practitioners who are not fire specialists.

Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate.

The enzyme 2-methylerythritol 2,4-cyclodiphosphate synthase, IspF, is essential for the biosynthesis of isoprenoids in most bacteria, some eukaryotic parasites, and the plastids of plant cells. The development of inhibitors that target IspF may lead to novel classes of anti-infective agents or herbicides. Enantiomers of tryptophan hydroxamate were synthesized and evaluated for binding to Burkholderia pseudomallei (Bp) IspF.

Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase.

Enzymes in the methylerythritol phosphate pathway make attractive targets for antibacterial activity due to their importance in isoprenoid biosynthesis and the absence of the pathway in mammals. The fifth enzyme in the pathway, 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase (IspF), contains a catalytically important zinc ion in the active site. A series of de novo designed compounds containing a zinc binding group was synthesized and evaluated for antibacterial activity and interaction with IspF from Burkholderia pseudomallei, the causative agent of Whitmore's disease.

Dissemination of Imidacloprid Through Dairy Cattle Manure and Its Effect on the Biological Control Agent, Spalangia endius (Hymenoptera: Pteromalidae), and a Filth Fly Host, Musca domestica (Diptera: Muscidae).

Filth flies, including house flies, Musca domestica L., develop in animal manure. Adult house flies often are controlled with pesticides such as imidacloprid.

()-4-Chloro--{3-[(4-chlorophenyl)sulfonyl]-2,3-dihydrobenzo[]thiazol-2-ylidene}benzene-sulfonamide.

The title compound, CHClNOS, is related to a ditosylated 2-iminobenzothiazole with the two methyl groups on the two phenyl rings replaced by chlorine. There is a weak intramolecular - contact between the two phenyl rings, with a centroid-to-centroid distance of 4.004 (2) Å.