Publications by authors named "Sydney Dumont"
Article Synopsis
- Gliomas consist of malignant cells that exhibit various cellular states, which are organized in distinct ways within the tumor.
- Research reveals three key modes of organization: localized environments with predominant cellular states, specific pairings of these states residing close to one another, and a global architecture consisting of five layers driven by hypoxia.
- The study emphasizes that hypoxia influences the spatial arrangement of these cellular states, while regions far from hypoxic areas show less organization, offering a novel framework for understanding glioma structure.
Cancer vaccine strategies for the treatment of diffusely infiltrating gliomas.
Ther Adv Vaccines Immunother
October 2023
Diffusely infiltrating gliomas - including glioblastoma (GBM), isocitrate dehydrogenase (IDH) mutant gliomas, and histone 3 (H3) altered gliomas - are primary brain tumors with an invariably fatal outcome. Despite advances in the understanding of their biology, standard, targeted and immune checkpoint inhibitor immunotherapies have proven ineffective in arresting their inexorable progression and associated morbidity and mortality. Recognizing the unique aspects of the immunogenicity of cancer cells, the last decade has seen the development and evaluation of vaccine-based therapies for the treatment of solid tumors, including gliomas.
View Article and Find Full Text PDFImmunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of cancer such as recurrent glioblastoma (rGBM). Here we report the results of a first-in-human phase I trial in 41 patients with rGBM who were injected with CAN-3110-an oncolytic herpes virus (oHSV). In contrast to other clinical oHSVs, CAN-3110 retains the viral neurovirulence ICP34.
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