Publications by authors named "Sydney Cornelius"
Article Synopsis
- Pregnancy leads to significant physiological changes that may affect brain injury outcomes, but there's limited understanding of this relationship.
- In an experiment with female mice, the impact of past pregnancies (multiparous) versus no pregnancies (nulliparous) on the brain's inflammatory response to traumatic brain injury (TBI) was studied.
- Results showed that while both groups exhibited increased inflammation markers after injury, multiparous mice had a reduced presence of certain immune cells and maintained better blood-brain barrier function, suggesting that a history of multiple pregnancies could positively influence neuroinflammatory responses post-TBI.
Traumatic brain injury (TBI) impairs the ability to restore homeostasis in response to stress, indicating hypothalamic-pituitary-adrenal (HPA)-axis dysfunction. Many stressors result in sleep disturbances, thus mechanical sleep fragmentation (SF) provides a physiologically relevant approach to study the effects of stress after injury. We hypothesize SF stress engages the dysregulated HPA-axis after TBI to exacerbate post-injury neuroinflammation and compromise recovery.
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